Biology of breast cancer bone metastasis

Mojtaba Akhtari, Junaid Mansuri, Kam A. Newman, Theresa M. Guise, Prem Seth

Research output: Contribution to journalReview articlepeer-review

118 Scopus citations

Abstract

Breast carcinoma ranks among the most prevalent malignancies in women. Breast carcinoma frequently metastasizes to bone and approximately 70% of patients with breast cancer have bone metastases, which generally are osteolytic lesions. They cause major morbidity and mortality in patients; and the available treatment options are limited. Bone-specific homing and colonization of cancer cells are important and interesting features of metastasis. There are complex and multiple steps in the process of bone metastasis; and the elaborate interaction between breast carcinoma and bone involves various cytokines, growth factors and cellular signals, which results in a vicious cycle and promotes tumor cell accumulation and osteolysis. Recent advances in molecular biology have resulted in major breakthroughs in our understanding of the pathogenesis of bone metastasis in breast cancer, which is critical in preventing metastasis, designing novel and targeted treatments and prolonging survival in this devastating condition.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalCancer Biology and Therapy
Volume7
Issue number1
DOIs
StatePublished - Jan 2008

Keywords

  • Bone metastasis
  • Breast cancer
  • IL-11
  • Osteoblasts
  • Osteoclasts
  • PTH-rP
  • RANKL
  • TGFβ

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research

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