Biology of LPA in health and disease

Saubhik Sengupta, Zeneng Wang, Russell Tipps, Yan Xu

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

The functions of lysophosphatidic acid (LPA) can be broadly divided into two classes: (1) physiological and (2) pathological roles. The role of LPA in embryonic development can be seen as early as oocyte formation. It continues in postnatal homeostasis, through its ability to impart a level of protection from both stress and local injury, by regulating cellular proliferation, apoptosis, and the reorganization of cytoskeletal fibers. LPA may function as a double-edged sword. While it helps maintain homeostasis against stress and insult, it may also augment the development and spread of pathological processes, including cancers.

Original languageEnglish (US)
Pages (from-to)503-512
Number of pages10
JournalSeminars in Cell and Developmental Biology
Volume15
Issue number5
DOIs
StatePublished - Jul 2004
Externally publishedYes

Keywords

  • Cancer
  • Lysophosphatidic acid (LPA)
  • Lysophospholipids
  • Pathology
  • Physiology

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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