Biomarkers for breast cancer stem cells

The challenges ahead

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Recent studies suggest that a subset of cancer cells with the ability for self-renewal and differentiation into different cell lineages is responsible for tumor progression, metastasis and resistance therapy. These cells, designated as tumor-initiating cells, tumor-propagating cells or cancer stem cells, are of great interest for cancer prognostication and therapeutics. Numerous cell surface and intracellular markers exhibiting cancer stem cell characteristics have been identified in breast cancer, presenting a promise to use them as biomarkers. However, there is a great need for the improvement of experimental methods to detect them in clinical samples, and validate their utility as predictors of the disease outcome, propensity for metastasis and response to treatment. In this article, we present an overview of the current status of breast cancer stem cells, with a focus on biomarkers. We also discuss the technical challenges on the road to defining breast cancer stem cells as biomarkers.

Original languageEnglish
Pages (from-to)661-671
Number of pages11
JournalBiomarkers in Medicine
Volume5
Issue number5
DOIs
StatePublished - Oct 2011

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Neoplastic Stem Cells
Biomarkers
Stem cells
Breast Neoplasms
Tumors
Neoplasms
Neoplasm Metastasis
Cell Lineage
Cells
Therapeutics

Keywords

  • basal stem/progenitor
  • biomarker
  • breast cancer stem cell
  • fluorescent-activated cell-sorting analysis
  • luminal progenitor
  • mammosphere assay
  • mature luminal cell
  • tumor-initiating cell

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Drug Discovery

Cite this

Biomarkers for breast cancer stem cells : The challenges ahead. / Polar, Yesim; Nakshatri, Harikrishna; Badve, Sunil.

In: Biomarkers in Medicine, Vol. 5, No. 5, 10.2011, p. 661-671.

Research output: Contribution to journalArticle

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