Biomarkers of Human Cardiopulmonary Response after Short-Term Exposures to Medical Laser-Generated Particulate Matter from Simulated Procedures A Pilot Study

Ramon Lopez, Mark O. Farber, Vincent Wong, Steven E. Lacey

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Objective: We conducted an exposure chamber study in humans using a simulated clinical procedure lasing porcine tissue to demonstrate evidence of effects of exposure to laser-generated particulate matter (LGPM). Methods: We measured pre-and post-exposure changes in exhaled nitric oxide (eNO), spirometry, heart rate variability (HRV), and blood markers of inflammation in five volunteers. Results: Change in pre-and post-exposure measurements of eNO and spirometry was unremarkable. Neutrophil and lymphocyte counts increased and fibrinogen levels decreased in four of the five subjects. Measures of HRV showed decreases in the standard deviation of normal between beat intervals and sequential 5-minute intervals. Conclusion: These data represent the first evidence of human physiologic response to LGPM exposure. Further exploration of coagulation effects and HRV is warranted.

Original languageEnglish (US)
Pages (from-to)940-945
Number of pages6
JournalJournal of Occupational and Environmental Medicine
Volume58
Issue number9
DOIs
StatePublished - Oct 19 2016

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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