Biomarkers of Human Cardiopulmonary Response after Short-Term Exposures to Medical Laser-Generated Particulate Matter from Simulated Procedures A Pilot Study

​Ramon ​Lopez, Mark O. Farber, Vincent Wong, Steven Lacey

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: We conducted an exposure chamber study in humans using a simulated clinical procedure lasing porcine tissue to demonstrate evidence of effects of exposure to laser-generated particulate matter (LGPM). Methods: We measured pre-and post-exposure changes in exhaled nitric oxide (eNO), spirometry, heart rate variability (HRV), and blood markers of inflammation in five volunteers. Results: Change in pre-and post-exposure measurements of eNO and spirometry was unremarkable. Neutrophil and lymphocyte counts increased and fibrinogen levels decreased in four of the five subjects. Measures of HRV showed decreases in the standard deviation of normal between beat intervals and sequential 5-minute intervals. Conclusion: These data represent the first evidence of human physiologic response to LGPM exposure. Further exploration of coagulation effects and HRV is warranted.

Original languageEnglish (US)
Pages (from-to)940-945
Number of pages6
JournalJournal of Occupational and Environmental Medicine
Volume58
Issue number9
DOIs
StatePublished - Oct 19 2016

Fingerprint

Particulate Matter
Lasers
Biomarkers
Heart Rate
Spirometry
Nitric Oxide
Lymphocyte Count
Fibrinogen
Volunteers
Neutrophils
Swine
Inflammation

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Biomarkers of Human Cardiopulmonary Response after Short-Term Exposures to Medical Laser-Generated Particulate Matter from Simulated Procedures A Pilot Study. / ​Lopez, ​Ramon; Farber, Mark O.; Wong, Vincent; Lacey, Steven.

In: Journal of Occupational and Environmental Medicine, Vol. 58, No. 9, 19.10.2016, p. 940-945.

Research output: Contribution to journalArticle

@article{8fa4a1e5c9884782b3e23e2050ae7412,
title = "Biomarkers of Human Cardiopulmonary Response after Short-Term Exposures to Medical Laser-Generated Particulate Matter from Simulated Procedures A Pilot Study",
abstract = "Objective: We conducted an exposure chamber study in humans using a simulated clinical procedure lasing porcine tissue to demonstrate evidence of effects of exposure to laser-generated particulate matter (LGPM). Methods: We measured pre-and post-exposure changes in exhaled nitric oxide (eNO), spirometry, heart rate variability (HRV), and blood markers of inflammation in five volunteers. Results: Change in pre-and post-exposure measurements of eNO and spirometry was unremarkable. Neutrophil and lymphocyte counts increased and fibrinogen levels decreased in four of the five subjects. Measures of HRV showed decreases in the standard deviation of normal between beat intervals and sequential 5-minute intervals. Conclusion: These data represent the first evidence of human physiologic response to LGPM exposure. Further exploration of coagulation effects and HRV is warranted.",
author = "​Ramon ​Lopez and Farber, {Mark O.} and Vincent Wong and Steven Lacey",
year = "2016",
month = "10",
day = "19",
doi = "10.1097/JOM.0000000000000832",
language = "English (US)",
volume = "58",
pages = "940--945",
journal = "Journal of Occupational and Environmental Medicine",
issn = "1076-2752",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Biomarkers of Human Cardiopulmonary Response after Short-Term Exposures to Medical Laser-Generated Particulate Matter from Simulated Procedures A Pilot Study

AU - ​Lopez, ​Ramon

AU - Farber, Mark O.

AU - Wong, Vincent

AU - Lacey, Steven

PY - 2016/10/19

Y1 - 2016/10/19

N2 - Objective: We conducted an exposure chamber study in humans using a simulated clinical procedure lasing porcine tissue to demonstrate evidence of effects of exposure to laser-generated particulate matter (LGPM). Methods: We measured pre-and post-exposure changes in exhaled nitric oxide (eNO), spirometry, heart rate variability (HRV), and blood markers of inflammation in five volunteers. Results: Change in pre-and post-exposure measurements of eNO and spirometry was unremarkable. Neutrophil and lymphocyte counts increased and fibrinogen levels decreased in four of the five subjects. Measures of HRV showed decreases in the standard deviation of normal between beat intervals and sequential 5-minute intervals. Conclusion: These data represent the first evidence of human physiologic response to LGPM exposure. Further exploration of coagulation effects and HRV is warranted.

AB - Objective: We conducted an exposure chamber study in humans using a simulated clinical procedure lasing porcine tissue to demonstrate evidence of effects of exposure to laser-generated particulate matter (LGPM). Methods: We measured pre-and post-exposure changes in exhaled nitric oxide (eNO), spirometry, heart rate variability (HRV), and blood markers of inflammation in five volunteers. Results: Change in pre-and post-exposure measurements of eNO and spirometry was unremarkable. Neutrophil and lymphocyte counts increased and fibrinogen levels decreased in four of the five subjects. Measures of HRV showed decreases in the standard deviation of normal between beat intervals and sequential 5-minute intervals. Conclusion: These data represent the first evidence of human physiologic response to LGPM exposure. Further exploration of coagulation effects and HRV is warranted.

UR - http://www.scopus.com/inward/record.url?scp=84979988424&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979988424&partnerID=8YFLogxK

U2 - 10.1097/JOM.0000000000000832

DO - 10.1097/JOM.0000000000000832

M3 - Article

VL - 58

SP - 940

EP - 945

JO - Journal of Occupational and Environmental Medicine

JF - Journal of Occupational and Environmental Medicine

SN - 1076-2752

IS - 9

ER -