Biomechanical and molecular regulation of bone remodeling

Alexander Robling, Alesha B. Castillo, Charles H. Turner

Research output: Contribution to journalArticle

622 Citations (Scopus)

Abstract

Bone is a dynamic tissue that is constantly renewed. The cell populations that participate in this process-the osteoblasts and osteoclasts-are derived from different progenitor pools that are under distinct molecular control mechanisms. Together, these cells form temporary anatomical structures, called basic multicellular units, that execute bone remodeling. A number of stimuli affect bone turnover, including hormones, cytokines, and mechanical stimuli. All of these factors affect the amount and quality of the tissue produced. Mechanical loading is a particularly potent stimulus for bone cells, which improves bone strength and inhibits bone loss with age. Like other materials, bone accumulates damage from loading, but, unlike engineering materials, bone is capable of self-repair. The molecular mechanisms by which bone adapts to loading and repairs damage are starting to become clear. Many of these processes have implications for bone health, disease, and the feasibility of living in weightless environments (e.g., spaceflight).

Original languageEnglish (US)
Pages (from-to)455-498
Number of pages44
JournalAnnual Review of Biomedical Engineering
Volume8
DOIs
StatePublished - 2006

Fingerprint

Bone Remodeling
Bone
Bone and Bones
Space Flight
Bone Diseases
Repair
Osteoclasts
Osteoblasts
Tissue
Hormones
Cytokines
Health
Cells
Population

Keywords

  • Bone density
  • Mechanotransduction
  • Osteoblast
  • Osteoclast
  • Osteocyte

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering

Cite this

Biomechanical and molecular regulation of bone remodeling. / Robling, Alexander; Castillo, Alesha B.; Turner, Charles H.

In: Annual Review of Biomedical Engineering, Vol. 8, 2006, p. 455-498.

Research output: Contribution to journalArticle

Robling, Alexander ; Castillo, Alesha B. ; Turner, Charles H. / Biomechanical and molecular regulation of bone remodeling. In: Annual Review of Biomedical Engineering. 2006 ; Vol. 8. pp. 455-498.
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