Biomolecule‐cell interactions and the regulation of myelopoiesis

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67 Scopus citations


The regulation of myelopoiesis in vivo most likely entails a complex set of interactions between cell-derived biomolecules and their target cells. Much of what we currently know of these interactions has been derived from studies in vitro utilizing techniques for the purification of both the biomolecules and the cells producing and responding to these factors. Stimulating and suppressing influences have been uncovered, and with the cloning and purification of biologically active factors, studies assessing the actions of these molecules in vivo have begun. From studies in vitro it is apparent that many of the purified molecules can have more than one action and that different molecules can collaborate in a synergistic manner to enhance or suppress functional endpoints.

Original languageEnglish (US)
Pages (from-to)378-405
Number of pages28
JournalThe International Journal of Cell Cloning
Issue number5
StatePublished - 1986


  • Acidic isoferritin
  • Colony‐stimulating factors
  • Interferons
  • Interleukins
  • Lactoferrin
  • Leukemia
  • Prostaglandins
  • Transferrin
  • Tumor necrosis factors

ASJC Scopus subject areas

  • Cell Biology

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