Biotransformation in Egyptian spiny mouse Acomys cahirinus

John B. Watkins, James W. LaFollette, Ruth A. Sanders

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The activities of several representative biotransformation enzymes were determined in male and female spiny mouse tissues. Cytochrome P450 monooxygenase activity toward benzo(a)pyrene was significantly greater in female spiny mouse intestine than in males. Activity toward benzphetamine in both sexes was high in the liver, with little activity in the kidney and intestine. Sulfotransferase activity was high in kidney and intestine of female spiny mice but undetectable in the same tissues in males. Hepatic glutathione s-transferase activity towards 1-chloro-2,4-dinitrobenzene in females was significantly higher than in males. UDP-Glucuronosyltransferase activity toward 1-naphthol in both sexes in the kidney was significantly higher than hepatic and intestinal activity. Intestinal N-acetyltransferase activity towards 2-aminofluorene and β-naphthylamine was significantly greater in females than males. No consistent relation appeared to exist between biotransformation activities in spiny mouse and those in other related rodent species.

Original languageEnglish (US)
Pages (from-to)101-107
Number of pages7
JournalComparative Biochemistry and Physiology. Part C: Comparative
Volume110
Issue number1
DOIs
StatePublished - Jan 1995

Keywords

  • 4-Methylumbelliferone
  • Epoxide hydrolase
  • Ethoxyresorufin
  • N-Acetyltransferase
  • Sigmodon hispidus
  • Sulfotransferase
  • UDP-glucuronosyltransferase

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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