Bis(adenosyl-5′)tetraphosphate as a partial agonist of ATP receptors in rat sensory neurons

S. M. Marchenko, A. G. Obukhov, T. M. Volkova, N. B. Tarusova

Research output: Contribution to journalArticle

1 Scopus citations


The effects of bis(adenosyl-5′)oligophosphates on cation conductance-promoting ATP receptors at the somatic membrane of rat sensory ganglia neurons were investigated. Both bis(adenosyl-5′)tetraphosphate and bis(adenosyl-5′)pentaphosphate act as partial agonists of ATP receptors at saturating concentration and activate ionic currents of almost one order of magnitude below the amplitude of peak ATP-activated currents. Combined application of these two substances to the neuron produces a considerable decline in the amplitude of ATP-activated ionic currents, competing with ATP for common binding sites.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
Issue number4
StatePublished - Jul 1988
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Fingerprint Dive into the research topics of 'Bis(adenosyl-5′)tetraphosphate as a partial agonist of ATP receptors in rat sensory neurons'. Together they form a unique fingerprint.

  • Cite this