Bis(adenosyl-5′)tetraphosphate as a partial agonist of ATP receptors in rat sensory neurons

S. M. Marchenko, Alexander Obukhov, T. M. Volkova, N. B. Tarusova

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effects of bis(adenosyl-5′)oligophosphates on cation conductance-promoting ATP receptors at the somatic membrane of rat sensory ganglia neurons were investigated. Both bis(adenosyl-5′)tetraphosphate and bis(adenosyl-5′)pentaphosphate act as partial agonists of ATP receptors at saturating concentration and activate ionic currents of almost one order of magnitude below the amplitude of peak ATP-activated currents. Combined application of these two substances to the neuron produces a considerable decline in the amplitude of ATP-activated ionic currents, competing with ATP for common binding sites.

Original languageEnglish
Pages (from-to)305-308
Number of pages4
JournalNeurophysiology
Volume20
Issue number4
DOIs
StatePublished - Jul 1988
Externally publishedYes

Fingerprint

Purinergic P2 Receptors
Sensory Receptor Cells
Adenosine Triphosphate
Sensory Ganglia
Cations
Binding Sites
Neurons
Membranes
diadenosine tetraphosphate

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Cite this

Bis(adenosyl-5′)tetraphosphate as a partial agonist of ATP receptors in rat sensory neurons. / Marchenko, S. M.; Obukhov, Alexander; Volkova, T. M.; Tarusova, N. B.

In: Neurophysiology, Vol. 20, No. 4, 07.1988, p. 305-308.

Research output: Contribution to journalArticle

Marchenko, S. M. ; Obukhov, Alexander ; Volkova, T. M. ; Tarusova, N. B. / Bis(adenosyl-5′)tetraphosphate as a partial agonist of ATP receptors in rat sensory neurons. In: Neurophysiology. 1988 ; Vol. 20, No. 4. pp. 305-308.
@article{3132c60cae664136a34bbb2c3bbde703,
title = "Bis(adenosyl-5′)tetraphosphate as a partial agonist of ATP receptors in rat sensory neurons",
abstract = "The effects of bis(adenosyl-5′)oligophosphates on cation conductance-promoting ATP receptors at the somatic membrane of rat sensory ganglia neurons were investigated. Both bis(adenosyl-5′)tetraphosphate and bis(adenosyl-5′)pentaphosphate act as partial agonists of ATP receptors at saturating concentration and activate ionic currents of almost one order of magnitude below the amplitude of peak ATP-activated currents. Combined application of these two substances to the neuron produces a considerable decline in the amplitude of ATP-activated ionic currents, competing with ATP for common binding sites.",
author = "Marchenko, {S. M.} and Alexander Obukhov and Volkova, {T. M.} and Tarusova, {N. B.}",
year = "1988",
month = "7",
doi = "10.1007/BF02198436",
language = "English",
volume = "20",
pages = "305--308",
journal = "Neurophysiology",
issn = "0090-2977",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Bis(adenosyl-5′)tetraphosphate as a partial agonist of ATP receptors in rat sensory neurons

AU - Marchenko, S. M.

AU - Obukhov, Alexander

AU - Volkova, T. M.

AU - Tarusova, N. B.

PY - 1988/7

Y1 - 1988/7

N2 - The effects of bis(adenosyl-5′)oligophosphates on cation conductance-promoting ATP receptors at the somatic membrane of rat sensory ganglia neurons were investigated. Both bis(adenosyl-5′)tetraphosphate and bis(adenosyl-5′)pentaphosphate act as partial agonists of ATP receptors at saturating concentration and activate ionic currents of almost one order of magnitude below the amplitude of peak ATP-activated currents. Combined application of these two substances to the neuron produces a considerable decline in the amplitude of ATP-activated ionic currents, competing with ATP for common binding sites.

AB - The effects of bis(adenosyl-5′)oligophosphates on cation conductance-promoting ATP receptors at the somatic membrane of rat sensory ganglia neurons were investigated. Both bis(adenosyl-5′)tetraphosphate and bis(adenosyl-5′)pentaphosphate act as partial agonists of ATP receptors at saturating concentration and activate ionic currents of almost one order of magnitude below the amplitude of peak ATP-activated currents. Combined application of these two substances to the neuron produces a considerable decline in the amplitude of ATP-activated ionic currents, competing with ATP for common binding sites.

UR - http://www.scopus.com/inward/record.url?scp=34250086831&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250086831&partnerID=8YFLogxK

U2 - 10.1007/BF02198436

DO - 10.1007/BF02198436

M3 - Article

AN - SCOPUS:34250086831

VL - 20

SP - 305

EP - 308

JO - Neurophysiology

JF - Neurophysiology

SN - 0090-2977

IS - 4

ER -