Bisphosphonate-associated osteonecrosis of the jaw

Report of a Task Force of the American Society for Bone and Mineral Research

Sundeep Khosla, David Burr, Jane Cauley, David W. Dempster, Peter R. Ebeling, Dieter Felsenberg, Robert F. Gagel, Vincente Gilsanz, Theresa Guise, Sreenivas Koka, Laurie K. McCauley, Joan McGowan, Marc D. McKee, Suresh Mohla, David G. Pendrys, Lawrence G. Raisz, Salvatore L. Ruggiero, David M. Shafer, Lillian Shum, Stuart L. Silverman & 4 others Catherine H. Van Poznak, Nelson Watts, Sook Bin Woo, Elizabeth Shane

Research output: Contribution to journalArticle

1123 Citations (Scopus)

Abstract

ONJ has been increasingly suspected to be a potential complication of bisphosphonate therapy in recent years. Thus, the ASBMR leadership appointed a multidisciplinary task force to address key questions related to case definition, epidemiology, risk factors, diagnostic imaging, clinical management, and future areas for research related to the disorder. This report summarizes the findings and recommendations of the task force. Introduction: The increasing recognition that use of bisphosphonates may be associated with osteonecrosis of the jaw (ONJ) led the leadership of the American Society for Bone and Mineral Research (ASBMR) to appoint a task force to address a number of key questions related to this disorder. Materials and Methods: A multidisciplinary expert group reviewed all pertinent published data on bisphosphonate-associated ONJ. Food and Drug Administration drug adverse event reports were also reviewed. Results and Conclusions: A case definition was developed so that subsequent studies could report on the same condition. The task force defined ONJ as the presence of exposed bone in the maxillofacial region that did not heal within 8 wk after identification by a health care provider. Based on review of both published and unpublished data, the risk of ONJ associated with oral bisphosphonate therapy for osteoporosis seems to be low, estimated between 1 in 10,000 and

Original languageEnglish (US)
Pages (from-to)1479-1491
Number of pages13
JournalJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume22
Issue number10
DOIs
StatePublished - Oct 2007
Externally publishedYes

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Bisphosphonate-Associated Osteonecrosis of the Jaw
Osteonecrosis
Advisory Committees
Jaw
Diphosphonates
Bone and Bones
Diagnostic Imaging
United States Food and Drug Administration
Drug-Related Side Effects and Adverse Reactions
Research
Health Personnel
Osteoporosis
Minerals
Epidemiology
Therapeutics

Keywords

  • Bone
  • Metastases
  • Oral cavity
  • Osteoporosis
  • Pain

ASJC Scopus subject areas

  • Surgery

Cite this

Bisphosphonate-associated osteonecrosis of the jaw : Report of a Task Force of the American Society for Bone and Mineral Research. / Khosla, Sundeep; Burr, David; Cauley, Jane; Dempster, David W.; Ebeling, Peter R.; Felsenberg, Dieter; Gagel, Robert F.; Gilsanz, Vincente; Guise, Theresa; Koka, Sreenivas; McCauley, Laurie K.; McGowan, Joan; McKee, Marc D.; Mohla, Suresh; Pendrys, David G.; Raisz, Lawrence G.; Ruggiero, Salvatore L.; Shafer, David M.; Shum, Lillian; Silverman, Stuart L.; Van Poznak, Catherine H.; Watts, Nelson; Woo, Sook Bin; Shane, Elizabeth.

In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 22, No. 10, 10.2007, p. 1479-1491.

Research output: Contribution to journalArticle

Khosla, S, Burr, D, Cauley, J, Dempster, DW, Ebeling, PR, Felsenberg, D, Gagel, RF, Gilsanz, V, Guise, T, Koka, S, McCauley, LK, McGowan, J, McKee, MD, Mohla, S, Pendrys, DG, Raisz, LG, Ruggiero, SL, Shafer, DM, Shum, L, Silverman, SL, Van Poznak, CH, Watts, N, Woo, SB & Shane, E 2007, 'Bisphosphonate-associated osteonecrosis of the jaw: Report of a Task Force of the American Society for Bone and Mineral Research', Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, vol. 22, no. 10, pp. 1479-1491. https://doi.org/10.1359/jbmr.0707onj
Khosla, Sundeep ; Burr, David ; Cauley, Jane ; Dempster, David W. ; Ebeling, Peter R. ; Felsenberg, Dieter ; Gagel, Robert F. ; Gilsanz, Vincente ; Guise, Theresa ; Koka, Sreenivas ; McCauley, Laurie K. ; McGowan, Joan ; McKee, Marc D. ; Mohla, Suresh ; Pendrys, David G. ; Raisz, Lawrence G. ; Ruggiero, Salvatore L. ; Shafer, David M. ; Shum, Lillian ; Silverman, Stuart L. ; Van Poznak, Catherine H. ; Watts, Nelson ; Woo, Sook Bin ; Shane, Elizabeth. / Bisphosphonate-associated osteonecrosis of the jaw : Report of a Task Force of the American Society for Bone and Mineral Research. In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2007 ; Vol. 22, No. 10. pp. 1479-1491.
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AU - Burr, David

AU - Cauley, Jane

AU - Dempster, David W.

AU - Ebeling, Peter R.

AU - Felsenberg, Dieter

AU - Gagel, Robert F.

AU - Gilsanz, Vincente

AU - Guise, Theresa

AU - Koka, Sreenivas

AU - McCauley, Laurie K.

AU - McGowan, Joan

AU - McKee, Marc D.

AU - Mohla, Suresh

AU - Pendrys, David G.

AU - Raisz, Lawrence G.

AU - Ruggiero, Salvatore L.

AU - Shafer, David M.

AU - Shum, Lillian

AU - Silverman, Stuart L.

AU - Van Poznak, Catherine H.

AU - Watts, Nelson

AU - Woo, Sook Bin

AU - Shane, Elizabeth

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