Bisphosphonate therapy for fibrous dysplasia

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Bony fibrous dysplasia is one of the hallmark features of McCune-Albright syndrome. Fibrous dysplasia can result in pain, fracture and deformity in affected areas. A number of observational, uncontrolled reports have been published outlining results of bisphosphonate therapy for fibrous dysplasia. Bisphosphonates are well tolerated and appear to be useful for reducing bone pain. Although their use is also associated with decreases in bone turnover, increases in bone density and radiological changes, their impact on the overall course of the disease, particularly the incidence of fractures and deformity, is less clear. Many questions remain about optimizing their use for fibrous dysplasia therapy.

Original languageEnglish (US)
Pages (from-to)440-445
Number of pages6
JournalPediatric Endocrinology Reviews
Volume4
Issue numberSUPPL. 4
StatePublished - Aug 1 2007

Keywords

  • Alendronate
  • Diphosphonates
  • Pain
  • Pamidronate alkaline phosphatase
  • Review
  • Zolendronic acid

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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