Bladder cancer, drinking water source, and tap water consumption

A case-control study

K. P. Cantor, R. Hoover, P. Hartge, T. J. Mason, D. T. Silverman, R. Altman, D. F. Austin, M. A. Child, C. R. Key, L. D. Marrett, M. H. Myers, A. S. Narayana, L. I. Levin, J. W. Sullivan, G. M. Swanson, D. B. Thomas, D. W. West

Research output: Contribution to journalArticle

191 Citations (Scopus)

Abstract

Data from a population-based case-control interview study of incident bladder cancer in 10 areas of the United States were used to estimate relative risks among white men (2,116 cases, 3,892 controls) and women (689 cases, 1,366 controls) according to beverage intake level and type of water source. Individual year-by-year profiles of water source and treatment were developed by linking lifetime residential information with historical water utility data from an ancillary survey. Risk of bladder cancer increased with intake level of beverages made with tap water. The odds ratio (OR) for the highest vs. lowest quintile of tap water consumption was 1.43 [95% confidence interval (CI) = 1.23, 1.67; χ2 for trend = 26.3, P <.001]. The risk gradient with intake was restricted to persons with at least a 40-year exposure to chlorinated surface water and was not found among long-term users of nonchlorinated ground water. The ORs for the highest vs. lowest quintiles of tap water intake were 1.7 and 2.0, respectively, among subjects with 40-59 and ≥60 years' exposure. Duration of exposure to chlorinated surface water was associated with bladder cancer risk among women and nonsmokers of both sexes. Among non-smoking respondents with tap water consumption above the population median, the OR increased with exposure duration to a level of 3.1 (CI = 1.3, 7.3; χ2 for trend = 6.3, P = .01) for ≥60 years of residence at places served by chlorinated surface water (vs. nonchlorinated gound water users). These results extend findings of earlier epidemiologic studies and are consistent with environmental chemistry and toxicologic data demonstrating the presence of genotoxic by-products of chlorine disinfection in treated surface waters.

Original languageEnglish (US)
Pages (from-to)1269-1279
Number of pages11
JournalJournal of the National Cancer Institute
Volume79
Issue number6
StatePublished - 1987
Externally publishedYes

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Urinary Bladder Neoplasms
Drinking Water
Drinking
Case-Control Studies
Water
Beverages
Odds Ratio
Confidence Intervals
Water Purification
Chlorine
Disinfection
Groundwater
Population
Epidemiologic Studies
Interviews

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cantor, K. P., Hoover, R., Hartge, P., Mason, T. J., Silverman, D. T., Altman, R., ... West, D. W. (1987). Bladder cancer, drinking water source, and tap water consumption: A case-control study. Journal of the National Cancer Institute, 79(6), 1269-1279.

Bladder cancer, drinking water source, and tap water consumption : A case-control study. / Cantor, K. P.; Hoover, R.; Hartge, P.; Mason, T. J.; Silverman, D. T.; Altman, R.; Austin, D. F.; Child, M. A.; Key, C. R.; Marrett, L. D.; Myers, M. H.; Narayana, A. S.; Levin, L. I.; Sullivan, J. W.; Swanson, G. M.; Thomas, D. B.; West, D. W.

In: Journal of the National Cancer Institute, Vol. 79, No. 6, 1987, p. 1269-1279.

Research output: Contribution to journalArticle

Cantor, KP, Hoover, R, Hartge, P, Mason, TJ, Silverman, DT, Altman, R, Austin, DF, Child, MA, Key, CR, Marrett, LD, Myers, MH, Narayana, AS, Levin, LI, Sullivan, JW, Swanson, GM, Thomas, DB & West, DW 1987, 'Bladder cancer, drinking water source, and tap water consumption: A case-control study', Journal of the National Cancer Institute, vol. 79, no. 6, pp. 1269-1279.
Cantor KP, Hoover R, Hartge P, Mason TJ, Silverman DT, Altman R et al. Bladder cancer, drinking water source, and tap water consumption: A case-control study. Journal of the National Cancer Institute. 1987;79(6):1269-1279.
Cantor, K. P. ; Hoover, R. ; Hartge, P. ; Mason, T. J. ; Silverman, D. T. ; Altman, R. ; Austin, D. F. ; Child, M. A. ; Key, C. R. ; Marrett, L. D. ; Myers, M. H. ; Narayana, A. S. ; Levin, L. I. ; Sullivan, J. W. ; Swanson, G. M. ; Thomas, D. B. ; West, D. W. / Bladder cancer, drinking water source, and tap water consumption : A case-control study. In: Journal of the National Cancer Institute. 1987 ; Vol. 79, No. 6. pp. 1269-1279.
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AU - Cantor, K. P.

AU - Hoover, R.

AU - Hartge, P.

AU - Mason, T. J.

AU - Silverman, D. T.

AU - Altman, R.

AU - Austin, D. F.

AU - Child, M. A.

AU - Key, C. R.

AU - Marrett, L. D.

AU - Myers, M. H.

AU - Narayana, A. S.

AU - Levin, L. I.

AU - Sullivan, J. W.

AU - Swanson, G. M.

AU - Thomas, D. B.

AU - West, D. W.

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N2 - Data from a population-based case-control interview study of incident bladder cancer in 10 areas of the United States were used to estimate relative risks among white men (2,116 cases, 3,892 controls) and women (689 cases, 1,366 controls) according to beverage intake level and type of water source. Individual year-by-year profiles of water source and treatment were developed by linking lifetime residential information with historical water utility data from an ancillary survey. Risk of bladder cancer increased with intake level of beverages made with tap water. The odds ratio (OR) for the highest vs. lowest quintile of tap water consumption was 1.43 [95% confidence interval (CI) = 1.23, 1.67; χ2 for trend = 26.3, P <.001]. The risk gradient with intake was restricted to persons with at least a 40-year exposure to chlorinated surface water and was not found among long-term users of nonchlorinated ground water. The ORs for the highest vs. lowest quintiles of tap water intake were 1.7 and 2.0, respectively, among subjects with 40-59 and ≥60 years' exposure. Duration of exposure to chlorinated surface water was associated with bladder cancer risk among women and nonsmokers of both sexes. Among non-smoking respondents with tap water consumption above the population median, the OR increased with exposure duration to a level of 3.1 (CI = 1.3, 7.3; χ2 for trend = 6.3, P = .01) for ≥60 years of residence at places served by chlorinated surface water (vs. nonchlorinated gound water users). These results extend findings of earlier epidemiologic studies and are consistent with environmental chemistry and toxicologic data demonstrating the presence of genotoxic by-products of chlorine disinfection in treated surface waters.

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