Bladder stones after bladder augmentation are not what they seem

Konrad Szymanski, Rosalia Misseri, Benjamin Whittam, James E. Lingeman, Sable Amstutz, Joshua D. Ring, Martin Kaefer, Richard C. Rink, Mark P. Cain

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction: Bladder and renal calculi after bladder augmentation are thought to be primarily infectious, yet few studies have reported stone composition. Objective: The primary aim was to assess bladder stone composition after augmentation, and renal stone composition in those with subsequent nephrolithiasis. The exploratory secondary aim was to screen for possible risk factors for developing infectious stones. Study design: Patients treated for bladder stones after bladder augmentation at the present institution between 1981 and 2012 were retrospectively reviewed. Data were collected on demographics, surgeries and stone composition. Patients without stone analysis were excluded. Stones containing struvite, carbonate apatite or ammonium acid ureate were classified as infectious. The following variables were analyzed for a possible association with infectious bladder stone composition: gender, history of cloacal exstrophy, ambulatory status, nephrolithiasis, recurrent urea-splitting urinary tract infections, first vs recurrent stones, timing of presentation with a calculus, history of bladder neck procedures, catheterizable channel and vesicoureteral reflux. Fisher's exact test was used for analysis. Results: Of the 107 patients with bladder stones after bladder augmentation, 85 met inclusion criteria. Median age at augmentation was 8.0 years (follow-up 10.8 years). Forty-four patients (51.8%) recurred (14 multiple recurrences, 143 bladder stones). Renal calculi developed in 19 (22.4%) patients with a bladder stone, and 10 (52.6%) recurred (30 renal stones).Overall, 30.8% of bladder stones were non-infectious (Table). Among patients recurring after an infectious bladder stone, 30.4% recurred with a non-infectious one. Among patients recurring after a non-infectious stone, 84.6% recurred with a non-infectious one (P=0.005).Compared with bladder stones, renal stones were more likely to be non-infectious (60.0%, P=0.003). Of patients with recurrent renal calculi after an infectious stone, 40.0% recurred with a non-infectious one.No clinical variables were significantly associated with infectious stone composition on univariate (≥0.28) or bivariate analysis (≥0.36). Discussion: This study had several limitations: it was not possible to accurately assess adherence with bladder irrigations, and routine metabolic evaluations were not performed. The findings may not apply to patients in all clinical settings. While stone analysis was available for 3/4 of the stones, similar rates of incomplete stone analyses have been reported in other series. Conclusions: In patients with bladder augmentation, 1/3 of bladder stones and >1/2 of renal stones were non-infectious. Furthermore, an infectious stone does not imply an infectious recurrent stone and no known clinical variables appear to be associated with stone composition, suggesting that there is a possible metabolic component in stone formation after bladder augmentation.TableStone composition of bladder and renal stones in patients with augmented bladders.Stone compositionBladder stones (n=143) (%)Renal stones (n=30) (%) Infectious stones 99 (69.2%) 12 (40.0%) Struvite79 (55.2%)11 (36.7%) Pure carbonate apatite15 (10.5%)1 (3.3%) Pure ammonium acid ureate2 (1.4%)0 (0.0%) Mixed stones with calcium phosphate4 (2.8%)0 (0.0%) Non-infectious stones 44 (30.8%) 18 (60.0%) Calcium phosphate41 (28.7%)14 (46.7%) Pure calcium oxalate0 (0.0%)4 (13.3%) Uric acid3 (2.1%)0 (0.0%)

Original languageEnglish (US)
JournalJournal of Pediatric Urology
DOIs
StateAccepted/In press - Nov 26 2014

Fingerprint

Urinary Bladder Calculi
Urinary Bladder
Kidney
Kidney Calculi
Nephrolithiasis
Calcium
Ammonium Compounds
Vesico-Ureteral Reflux
Acids
Carbonates
Urinary Tract Infections
Urea

Keywords

  • Kidney stone
  • Urinary bladder
  • Urinary bladder calculi
  • Urinary diversion

ASJC Scopus subject areas

  • Urology
  • Pediatrics, Perinatology, and Child Health

Cite this

Bladder stones after bladder augmentation are not what they seem. / Szymanski, Konrad; Misseri, Rosalia; Whittam, Benjamin; Lingeman, James E.; Amstutz, Sable; Ring, Joshua D.; Kaefer, Martin; Rink, Richard C.; Cain, Mark P.

In: Journal of Pediatric Urology, 26.11.2014.

Research output: Contribution to journalArticle

Szymanski, Konrad ; Misseri, Rosalia ; Whittam, Benjamin ; Lingeman, James E. ; Amstutz, Sable ; Ring, Joshua D. ; Kaefer, Martin ; Rink, Richard C. ; Cain, Mark P. / Bladder stones after bladder augmentation are not what they seem. In: Journal of Pediatric Urology. 2014.
@article{a485205514d14e1a95044a37f2d6396c,
title = "Bladder stones after bladder augmentation are not what they seem",
abstract = "Introduction: Bladder and renal calculi after bladder augmentation are thought to be primarily infectious, yet few studies have reported stone composition. Objective: The primary aim was to assess bladder stone composition after augmentation, and renal stone composition in those with subsequent nephrolithiasis. The exploratory secondary aim was to screen for possible risk factors for developing infectious stones. Study design: Patients treated for bladder stones after bladder augmentation at the present institution between 1981 and 2012 were retrospectively reviewed. Data were collected on demographics, surgeries and stone composition. Patients without stone analysis were excluded. Stones containing struvite, carbonate apatite or ammonium acid ureate were classified as infectious. The following variables were analyzed for a possible association with infectious bladder stone composition: gender, history of cloacal exstrophy, ambulatory status, nephrolithiasis, recurrent urea-splitting urinary tract infections, first vs recurrent stones, timing of presentation with a calculus, history of bladder neck procedures, catheterizable channel and vesicoureteral reflux. Fisher's exact test was used for analysis. Results: Of the 107 patients with bladder stones after bladder augmentation, 85 met inclusion criteria. Median age at augmentation was 8.0 years (follow-up 10.8 years). Forty-four patients (51.8{\%}) recurred (14 multiple recurrences, 143 bladder stones). Renal calculi developed in 19 (22.4{\%}) patients with a bladder stone, and 10 (52.6{\%}) recurred (30 renal stones).Overall, 30.8{\%} of bladder stones were non-infectious (Table). Among patients recurring after an infectious bladder stone, 30.4{\%} recurred with a non-infectious one. Among patients recurring after a non-infectious stone, 84.6{\%} recurred with a non-infectious one (P=0.005).Compared with bladder stones, renal stones were more likely to be non-infectious (60.0{\%}, P=0.003). Of patients with recurrent renal calculi after an infectious stone, 40.0{\%} recurred with a non-infectious one.No clinical variables were significantly associated with infectious stone composition on univariate (≥0.28) or bivariate analysis (≥0.36). Discussion: This study had several limitations: it was not possible to accurately assess adherence with bladder irrigations, and routine metabolic evaluations were not performed. The findings may not apply to patients in all clinical settings. While stone analysis was available for 3/4 of the stones, similar rates of incomplete stone analyses have been reported in other series. Conclusions: In patients with bladder augmentation, 1/3 of bladder stones and >1/2 of renal stones were non-infectious. Furthermore, an infectious stone does not imply an infectious recurrent stone and no known clinical variables appear to be associated with stone composition, suggesting that there is a possible metabolic component in stone formation after bladder augmentation.TableStone composition of bladder and renal stones in patients with augmented bladders.Stone compositionBladder stones (n=143) ({\%})Renal stones (n=30) ({\%}) Infectious stones 99 (69.2{\%}) 12 (40.0{\%}) Struvite79 (55.2{\%})11 (36.7{\%}) Pure carbonate apatite15 (10.5{\%})1 (3.3{\%}) Pure ammonium acid ureate2 (1.4{\%})0 (0.0{\%}) Mixed stones with calcium phosphate4 (2.8{\%})0 (0.0{\%}) Non-infectious stones 44 (30.8{\%}) 18 (60.0{\%}) Calcium phosphate41 (28.7{\%})14 (46.7{\%}) Pure calcium oxalate0 (0.0{\%})4 (13.3{\%}) Uric acid3 (2.1{\%})0 (0.0{\%})",
keywords = "Kidney stone, Urinary bladder, Urinary bladder calculi, Urinary diversion",
author = "Konrad Szymanski and Rosalia Misseri and Benjamin Whittam and Lingeman, {James E.} and Sable Amstutz and Ring, {Joshua D.} and Martin Kaefer and Rink, {Richard C.} and Cain, {Mark P.}",
year = "2014",
month = "11",
day = "26",
doi = "10.1016/j.jpurol.2015.06.021",
language = "English (US)",
journal = "Journal of Pediatric Urology",
issn = "1477-5131",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Bladder stones after bladder augmentation are not what they seem

AU - Szymanski, Konrad

AU - Misseri, Rosalia

AU - Whittam, Benjamin

AU - Lingeman, James E.

AU - Amstutz, Sable

AU - Ring, Joshua D.

AU - Kaefer, Martin

AU - Rink, Richard C.

AU - Cain, Mark P.

PY - 2014/11/26

Y1 - 2014/11/26

N2 - Introduction: Bladder and renal calculi after bladder augmentation are thought to be primarily infectious, yet few studies have reported stone composition. Objective: The primary aim was to assess bladder stone composition after augmentation, and renal stone composition in those with subsequent nephrolithiasis. The exploratory secondary aim was to screen for possible risk factors for developing infectious stones. Study design: Patients treated for bladder stones after bladder augmentation at the present institution between 1981 and 2012 were retrospectively reviewed. Data were collected on demographics, surgeries and stone composition. Patients without stone analysis were excluded. Stones containing struvite, carbonate apatite or ammonium acid ureate were classified as infectious. The following variables were analyzed for a possible association with infectious bladder stone composition: gender, history of cloacal exstrophy, ambulatory status, nephrolithiasis, recurrent urea-splitting urinary tract infections, first vs recurrent stones, timing of presentation with a calculus, history of bladder neck procedures, catheterizable channel and vesicoureteral reflux. Fisher's exact test was used for analysis. Results: Of the 107 patients with bladder stones after bladder augmentation, 85 met inclusion criteria. Median age at augmentation was 8.0 years (follow-up 10.8 years). Forty-four patients (51.8%) recurred (14 multiple recurrences, 143 bladder stones). Renal calculi developed in 19 (22.4%) patients with a bladder stone, and 10 (52.6%) recurred (30 renal stones).Overall, 30.8% of bladder stones were non-infectious (Table). Among patients recurring after an infectious bladder stone, 30.4% recurred with a non-infectious one. Among patients recurring after a non-infectious stone, 84.6% recurred with a non-infectious one (P=0.005).Compared with bladder stones, renal stones were more likely to be non-infectious (60.0%, P=0.003). Of patients with recurrent renal calculi after an infectious stone, 40.0% recurred with a non-infectious one.No clinical variables were significantly associated with infectious stone composition on univariate (≥0.28) or bivariate analysis (≥0.36). Discussion: This study had several limitations: it was not possible to accurately assess adherence with bladder irrigations, and routine metabolic evaluations were not performed. The findings may not apply to patients in all clinical settings. While stone analysis was available for 3/4 of the stones, similar rates of incomplete stone analyses have been reported in other series. Conclusions: In patients with bladder augmentation, 1/3 of bladder stones and >1/2 of renal stones were non-infectious. Furthermore, an infectious stone does not imply an infectious recurrent stone and no known clinical variables appear to be associated with stone composition, suggesting that there is a possible metabolic component in stone formation after bladder augmentation.TableStone composition of bladder and renal stones in patients with augmented bladders.Stone compositionBladder stones (n=143) (%)Renal stones (n=30) (%) Infectious stones 99 (69.2%) 12 (40.0%) Struvite79 (55.2%)11 (36.7%) Pure carbonate apatite15 (10.5%)1 (3.3%) Pure ammonium acid ureate2 (1.4%)0 (0.0%) Mixed stones with calcium phosphate4 (2.8%)0 (0.0%) Non-infectious stones 44 (30.8%) 18 (60.0%) Calcium phosphate41 (28.7%)14 (46.7%) Pure calcium oxalate0 (0.0%)4 (13.3%) Uric acid3 (2.1%)0 (0.0%)

AB - Introduction: Bladder and renal calculi after bladder augmentation are thought to be primarily infectious, yet few studies have reported stone composition. Objective: The primary aim was to assess bladder stone composition after augmentation, and renal stone composition in those with subsequent nephrolithiasis. The exploratory secondary aim was to screen for possible risk factors for developing infectious stones. Study design: Patients treated for bladder stones after bladder augmentation at the present institution between 1981 and 2012 were retrospectively reviewed. Data were collected on demographics, surgeries and stone composition. Patients without stone analysis were excluded. Stones containing struvite, carbonate apatite or ammonium acid ureate were classified as infectious. The following variables were analyzed for a possible association with infectious bladder stone composition: gender, history of cloacal exstrophy, ambulatory status, nephrolithiasis, recurrent urea-splitting urinary tract infections, first vs recurrent stones, timing of presentation with a calculus, history of bladder neck procedures, catheterizable channel and vesicoureteral reflux. Fisher's exact test was used for analysis. Results: Of the 107 patients with bladder stones after bladder augmentation, 85 met inclusion criteria. Median age at augmentation was 8.0 years (follow-up 10.8 years). Forty-four patients (51.8%) recurred (14 multiple recurrences, 143 bladder stones). Renal calculi developed in 19 (22.4%) patients with a bladder stone, and 10 (52.6%) recurred (30 renal stones).Overall, 30.8% of bladder stones were non-infectious (Table). Among patients recurring after an infectious bladder stone, 30.4% recurred with a non-infectious one. Among patients recurring after a non-infectious stone, 84.6% recurred with a non-infectious one (P=0.005).Compared with bladder stones, renal stones were more likely to be non-infectious (60.0%, P=0.003). Of patients with recurrent renal calculi after an infectious stone, 40.0% recurred with a non-infectious one.No clinical variables were significantly associated with infectious stone composition on univariate (≥0.28) or bivariate analysis (≥0.36). Discussion: This study had several limitations: it was not possible to accurately assess adherence with bladder irrigations, and routine metabolic evaluations were not performed. The findings may not apply to patients in all clinical settings. While stone analysis was available for 3/4 of the stones, similar rates of incomplete stone analyses have been reported in other series. Conclusions: In patients with bladder augmentation, 1/3 of bladder stones and >1/2 of renal stones were non-infectious. Furthermore, an infectious stone does not imply an infectious recurrent stone and no known clinical variables appear to be associated with stone composition, suggesting that there is a possible metabolic component in stone formation after bladder augmentation.TableStone composition of bladder and renal stones in patients with augmented bladders.Stone compositionBladder stones (n=143) (%)Renal stones (n=30) (%) Infectious stones 99 (69.2%) 12 (40.0%) Struvite79 (55.2%)11 (36.7%) Pure carbonate apatite15 (10.5%)1 (3.3%) Pure ammonium acid ureate2 (1.4%)0 (0.0%) Mixed stones with calcium phosphate4 (2.8%)0 (0.0%) Non-infectious stones 44 (30.8%) 18 (60.0%) Calcium phosphate41 (28.7%)14 (46.7%) Pure calcium oxalate0 (0.0%)4 (13.3%) Uric acid3 (2.1%)0 (0.0%)

KW - Kidney stone

KW - Urinary bladder

KW - Urinary bladder calculi

KW - Urinary diversion

UR - http://www.scopus.com/inward/record.url?scp=84944096570&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944096570&partnerID=8YFLogxK

U2 - 10.1016/j.jpurol.2015.06.021

DO - 10.1016/j.jpurol.2015.06.021

M3 - Article

JO - Journal of Pediatric Urology

JF - Journal of Pediatric Urology

SN - 1477-5131

ER -