Blastomycosis in Indiana

Digging up more cases

William Carlos, Anthony S. Rose, L. Joseph Wheat, Steven Norris, George A. Sarosi, Kenneth S. Knox, Chadi Hage

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: The endemic region of blastomycosis historically has included the state of Indiana. However, few published reports of blastomycosis exist to substantiate this distinction. A surge of patients with blastomycosis in central Indiana (Indianapolis and surrounding counties) beginning in 2005 prompted us to review our local experience. We propose that this surge was related to major highway construction around Indianapolis. Methods: We reviewed all microbiologically confirmed cases from four hospitals serving central Indiana. Chart review was completed for adult patients, and data were collected on clinical presentations, methods of diagnosis, comorbidities, radiologic findings, treatment, and outcomes. We plotted patient residence addresses with sites of highway construction. Results: Fifty-nine patients were identified from laboratory results and physician referral. Interestingly, a surge of blastomycosis incidence occurred in 34 patients between 2005 and 2008 during which time major highway projects were under way around the Indianapolis metropolitan area. The majority of these patients presented acutely and with pulmonary involvement. Fungal culture and antigen testing were the most sensitive means to diagnosis. Antifungal therapy was highly effective. Conclusions: This urban outbreak of blastomycosis in Indianapolis should prompt clinicians to consider blastomycosis in this highly endemic area of histoplasmosis.

Original languageEnglish
Pages (from-to)1377-1382
Number of pages6
JournalChest
Volume138
Issue number6
DOIs
StatePublished - Dec 1 2010

Fingerprint

Blastomycosis
Fungal Antigens
Histoplasmosis
Disease Outbreaks
Comorbidity
Referral and Consultation
Physicians
Lung
Incidence

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Carlos, W., Rose, A. S., Wheat, L. J., Norris, S., Sarosi, G. A., Knox, K. S., & Hage, C. (2010). Blastomycosis in Indiana: Digging up more cases. Chest, 138(6), 1377-1382. https://doi.org/10.1378/chest.10-0627

Blastomycosis in Indiana : Digging up more cases. / Carlos, William; Rose, Anthony S.; Wheat, L. Joseph; Norris, Steven; Sarosi, George A.; Knox, Kenneth S.; Hage, Chadi.

In: Chest, Vol. 138, No. 6, 01.12.2010, p. 1377-1382.

Research output: Contribution to journalArticle

Carlos, W, Rose, AS, Wheat, LJ, Norris, S, Sarosi, GA, Knox, KS & Hage, C 2010, 'Blastomycosis in Indiana: Digging up more cases', Chest, vol. 138, no. 6, pp. 1377-1382. https://doi.org/10.1378/chest.10-0627
Carlos W, Rose AS, Wheat LJ, Norris S, Sarosi GA, Knox KS et al. Blastomycosis in Indiana: Digging up more cases. Chest. 2010 Dec 1;138(6):1377-1382. https://doi.org/10.1378/chest.10-0627
Carlos, William ; Rose, Anthony S. ; Wheat, L. Joseph ; Norris, Steven ; Sarosi, George A. ; Knox, Kenneth S. ; Hage, Chadi. / Blastomycosis in Indiana : Digging up more cases. In: Chest. 2010 ; Vol. 138, No. 6. pp. 1377-1382.
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