Bleomycin serum pharmacokinetics as determined by a radioimmunoassay and a microbiologic assay in a patient with compromised renal function

Stanley T. Crooke, Friedrich Luft, Alan Broughton, James Strong, Kay Casson, Lawrence Einhorn

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Serum and plasma bleomycin concentrations were determined in a patient with renal dysfunction at two creatinine clearances. The results obtained with a new radioimmunoassay and the microbiologic assay were compared. It was shown: 1) that the clearance of bleomycin from the blood is markedly retarded in severe renal dysfunction, 2) that clearance of bleomycin varies with creatinine clearance, 3) that bleomycin is probably not dialyzable, 4) that determinations on serum and plasma were equivalent, and 5) that the radioimmunoassay and microbiologic assays gave equivalent results (P < 0.001).

Original languageEnglish (US)
Pages (from-to)1430-1434
Number of pages5
JournalCancer
Volume39
Issue number4
DOIs
StatePublished - Apr 1977

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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