Bleomycin serum pharmacokinetics as determined by a radioimmunoassay and a microbiologic assay in a patient with compromised renal function

S. T. Crooke, F. Luft, A. Broughton, J. Strong, K. Casson, Lawrence Einhorn

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Serum and plasma bleomycin concentrations were determined in a patient with renal dysfunction at two creatinine clearances. The results obtained with a new radioimmunoassay and the microbiologic assay were compared. The clearance of bleomycin from the blood is markedly retarded in severe renal dysfunction and varies with creatinine clearance. Bleomycin is probably not dialyzable; determinations on serum and plasma were equivalent, and the radioimmunoassay and microbiologic assays gave equivalent results (P

Original languageEnglish (US)
Pages (from-to)1430-1434
Number of pages5
JournalCancer
Volume39
Issue number4
StatePublished - 1977

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Bleomycin
Radioimmunoassay
Pharmacokinetics
Kidney
Creatinine
Serum

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bleomycin serum pharmacokinetics as determined by a radioimmunoassay and a microbiologic assay in a patient with compromised renal function. / Crooke, S. T.; Luft, F.; Broughton, A.; Strong, J.; Casson, K.; Einhorn, Lawrence.

In: Cancer, Vol. 39, No. 4, 1977, p. 1430-1434.

Research output: Contribution to journalArticle

Crooke, S. T. ; Luft, F. ; Broughton, A. ; Strong, J. ; Casson, K. ; Einhorn, Lawrence. / Bleomycin serum pharmacokinetics as determined by a radioimmunoassay and a microbiologic assay in a patient with compromised renal function. In: Cancer. 1977 ; Vol. 39, No. 4. pp. 1430-1434.
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