An inflammatory environment threatens the stability of Foxp3 + Treg cells. Garg et al. show that by expressing the transcriptional regulator Blimp1, Treg cells resist the IL-6-driven loss of Foxp3 in inflamed tissues. Blimp1 prevents the methylation and reduced expression of Foxp3 through inhibition of the methyltransferase Dnmt3a.
- DNA methyltransferases
- epigenetic regulation
- regulatory T cells
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)