Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation

Garima Garg, Andreas Muschaweckh, Helena Moreno, Ajithkumar Vasanthakumar, Stefan Floess, Gildas Lepennetier, Rupert Oellinger, Yifan Zhan, Tommy Regen, Michael Hiltensperger, Christian Peter, Lilian Aly, Benjamin Knier, Lakshmi Reddy Palam, Reuben Kapur, Mark H. Kaplan, Ari Waisman, Roland Rad, Gunnar Schotta, Jochen HuehnAxel Kallies, Thomas Korn

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

An inflammatory environment threatens the stability of Foxp3 + Treg cells. Garg et al. show that by expressing the transcriptional regulator Blimp1, Treg cells resist the IL-6-driven loss of Foxp3 in inflamed tissues. Blimp1 prevents the methylation and reduced expression of Foxp3 through inhibition of the methyltransferase Dnmt3a.

Original languageEnglish (US)
Pages (from-to)1854-1868.e5
JournalCell Reports
Volume26
Issue number7
DOIs
StatePublished - Feb 12 2019

Keywords

  • Blimp1
  • CNS
  • CNS2
  • DNA methyltransferases
  • Foxp3
  • Interleukin-6
  • epigenetic regulation
  • inflammation
  • regulatory T cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Garg, G., Muschaweckh, A., Moreno, H., Vasanthakumar, A., Floess, S., Lepennetier, G., Oellinger, R., Zhan, Y., Regen, T., Hiltensperger, M., Peter, C., Aly, L., Knier, B., Palam, L. R., Kapur, R., Kaplan, M. H., Waisman, A., Rad, R., Schotta, G., ... Korn, T. (2019). Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation. Cell Reports, 26(7), 1854-1868.e5. https://doi.org/10.1016/j.celrep.2019.01.070