Blinded and seeing the light, (John Noseworthy, Lou Gehrig and other tales of enlightenment)

Research output: Contribution to journalShort survey

4 Scopus citations


Patients having serious neurological diseases often wonder why clinical trials must use controls and double blinding in order to prove efficacy. Studies on the effect of examiner blinding in multiple sclerosis trials, as well as the published results of an unblinded uncontrolled clinical trial of Vitamin E therapy in patients with amyotrophic lateral sclerosis (including Lou Gehrig) provide clear illustrations of the impact of blinding and controls on outcome. These reports serve as a resource for physicians, patients and their families in discussing the rationale for controls and double blinding, and instill caution that should be used when judging results of studies which are unblinded or uncontrolled.

Original languageEnglish (US)
Pages (from-to)415-418
Number of pages4
JournalSeminars in Neurology
Issue number3
StatePublished - Jan 1 1998
Externally publishedYes


  • Amyotrophic lateral sclerosis
  • Clinical trials
  • Double blinding
  • Lou Gehrig
  • Multiple sclerosis
  • Noseworthy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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