Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: A meta-analysis of prospective studies

Yiqing Song, Lu Wang, Anastassios G. Pittas, Liana C. Del Gobbo, Cuilin Zhang, Joann E. Manson, Frank B. Hu

Research output: Contribution to journalArticle

254 Citations (Scopus)

Abstract

OBJECTIVE-To quantitatively assess the strength and shape of the association between blood 25-hydroxy vitamin D [25(OH)D] levels and incident risk of type 2 diabetes. RESEARCH DESIGN AND METHODS-A systematic search of the MEDLINE and Embase databases and a hand search of references from original reports were conducted up to 31 October 2012. Prospective observational studies that assessed the association between blood levels of 25(OH)D and risk of incident type 2 diabetes were included for meta-analysis. DerSimonian and Laird's random-effectsmodel was used. A quadratic spline regression analysis was used to examine the shape of the association with a generalized least-squares trend test performed for the dose-response relation. RESULTS-A total of 21 prospective studies involving 76,220 participants and 4,996 incident type 2 diabetes cases were included for meta-analysis. Comparing the highest to the lowest category of 25(OH)D levels, the summary relative risk for type 2 diabetes was 0.62 (95% CI 0.54-0.70). A spline regression model showed that higher 25(OH)D levels were monotonically associated with a lower diabetes risk. This inverse association did not differ by sex, duration of follow-up, study sample size, diabetes diagnostic criteria, or 25(OH)D assay method. A linear trend analysis showed that each 10 nmol/L increment in 25(OH)D levels was associated with a 4% lower risk of type 2 diabetes (95% CI 3-6; P for linear trend , 0.0001). CONCLUSIONS-Our meta-analysis showed an inverse and significant association between circulating 25(OH)D levels and risk of type 2 diabetes across a broad range of blood 25(OH)D levels in diverse populations.

Original languageEnglish (US)
Pages (from-to)1422-1428
Number of pages7
JournalDiabetes Care
Volume36
Issue number5
DOIs
StatePublished - May 1 2013
Externally publishedYes

Fingerprint

Vitamin D
Type 2 Diabetes Mellitus
Meta-Analysis
Prospective Studies
Least-Squares Analysis
MEDLINE
Sample Size
Observational Studies
Research Design
Regression Analysis
Databases
Population

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Song, Y., Wang, L., Pittas, A. G., Del Gobbo, L. C., Zhang, C., Manson, J. E., & Hu, F. B. (2013). Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: A meta-analysis of prospective studies. Diabetes Care, 36(5), 1422-1428. https://doi.org/10.2337/dc12-0962

Blood 25-hydroxy vitamin D levels and incident type 2 diabetes : A meta-analysis of prospective studies. / Song, Yiqing; Wang, Lu; Pittas, Anastassios G.; Del Gobbo, Liana C.; Zhang, Cuilin; Manson, Joann E.; Hu, Frank B.

In: Diabetes Care, Vol. 36, No. 5, 01.05.2013, p. 1422-1428.

Research output: Contribution to journalArticle

Song, Y, Wang, L, Pittas, AG, Del Gobbo, LC, Zhang, C, Manson, JE & Hu, FB 2013, 'Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: A meta-analysis of prospective studies', Diabetes Care, vol. 36, no. 5, pp. 1422-1428. https://doi.org/10.2337/dc12-0962
Song, Yiqing ; Wang, Lu ; Pittas, Anastassios G. ; Del Gobbo, Liana C. ; Zhang, Cuilin ; Manson, Joann E. ; Hu, Frank B. / Blood 25-hydroxy vitamin D levels and incident type 2 diabetes : A meta-analysis of prospective studies. In: Diabetes Care. 2013 ; Vol. 36, No. 5. pp. 1422-1428.
@article{62de59b36981498baa584ca96b13acc7,
title = "Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: A meta-analysis of prospective studies",
abstract = "OBJECTIVE-To quantitatively assess the strength and shape of the association between blood 25-hydroxy vitamin D [25(OH)D] levels and incident risk of type 2 diabetes. RESEARCH DESIGN AND METHODS-A systematic search of the MEDLINE and Embase databases and a hand search of references from original reports were conducted up to 31 October 2012. Prospective observational studies that assessed the association between blood levels of 25(OH)D and risk of incident type 2 diabetes were included for meta-analysis. DerSimonian and Laird's random-effectsmodel was used. A quadratic spline regression analysis was used to examine the shape of the association with a generalized least-squares trend test performed for the dose-response relation. RESULTS-A total of 21 prospective studies involving 76,220 participants and 4,996 incident type 2 diabetes cases were included for meta-analysis. Comparing the highest to the lowest category of 25(OH)D levels, the summary relative risk for type 2 diabetes was 0.62 (95{\%} CI 0.54-0.70). A spline regression model showed that higher 25(OH)D levels were monotonically associated with a lower diabetes risk. This inverse association did not differ by sex, duration of follow-up, study sample size, diabetes diagnostic criteria, or 25(OH)D assay method. A linear trend analysis showed that each 10 nmol/L increment in 25(OH)D levels was associated with a 4{\%} lower risk of type 2 diabetes (95{\%} CI 3-6; P for linear trend , 0.0001). CONCLUSIONS-Our meta-analysis showed an inverse and significant association between circulating 25(OH)D levels and risk of type 2 diabetes across a broad range of blood 25(OH)D levels in diverse populations.",
author = "Yiqing Song and Lu Wang and Pittas, {Anastassios G.} and {Del Gobbo}, {Liana C.} and Cuilin Zhang and Manson, {Joann E.} and Hu, {Frank B.}",
year = "2013",
month = "5",
day = "1",
doi = "10.2337/dc12-0962",
language = "English (US)",
volume = "36",
pages = "1422--1428",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "5",

}

TY - JOUR

T1 - Blood 25-hydroxy vitamin D levels and incident type 2 diabetes

T2 - A meta-analysis of prospective studies

AU - Song, Yiqing

AU - Wang, Lu

AU - Pittas, Anastassios G.

AU - Del Gobbo, Liana C.

AU - Zhang, Cuilin

AU - Manson, Joann E.

AU - Hu, Frank B.

PY - 2013/5/1

Y1 - 2013/5/1

N2 - OBJECTIVE-To quantitatively assess the strength and shape of the association between blood 25-hydroxy vitamin D [25(OH)D] levels and incident risk of type 2 diabetes. RESEARCH DESIGN AND METHODS-A systematic search of the MEDLINE and Embase databases and a hand search of references from original reports were conducted up to 31 October 2012. Prospective observational studies that assessed the association between blood levels of 25(OH)D and risk of incident type 2 diabetes were included for meta-analysis. DerSimonian and Laird's random-effectsmodel was used. A quadratic spline regression analysis was used to examine the shape of the association with a generalized least-squares trend test performed for the dose-response relation. RESULTS-A total of 21 prospective studies involving 76,220 participants and 4,996 incident type 2 diabetes cases were included for meta-analysis. Comparing the highest to the lowest category of 25(OH)D levels, the summary relative risk for type 2 diabetes was 0.62 (95% CI 0.54-0.70). A spline regression model showed that higher 25(OH)D levels were monotonically associated with a lower diabetes risk. This inverse association did not differ by sex, duration of follow-up, study sample size, diabetes diagnostic criteria, or 25(OH)D assay method. A linear trend analysis showed that each 10 nmol/L increment in 25(OH)D levels was associated with a 4% lower risk of type 2 diabetes (95% CI 3-6; P for linear trend , 0.0001). CONCLUSIONS-Our meta-analysis showed an inverse and significant association between circulating 25(OH)D levels and risk of type 2 diabetes across a broad range of blood 25(OH)D levels in diverse populations.

AB - OBJECTIVE-To quantitatively assess the strength and shape of the association between blood 25-hydroxy vitamin D [25(OH)D] levels and incident risk of type 2 diabetes. RESEARCH DESIGN AND METHODS-A systematic search of the MEDLINE and Embase databases and a hand search of references from original reports were conducted up to 31 October 2012. Prospective observational studies that assessed the association between blood levels of 25(OH)D and risk of incident type 2 diabetes were included for meta-analysis. DerSimonian and Laird's random-effectsmodel was used. A quadratic spline regression analysis was used to examine the shape of the association with a generalized least-squares trend test performed for the dose-response relation. RESULTS-A total of 21 prospective studies involving 76,220 participants and 4,996 incident type 2 diabetes cases were included for meta-analysis. Comparing the highest to the lowest category of 25(OH)D levels, the summary relative risk for type 2 diabetes was 0.62 (95% CI 0.54-0.70). A spline regression model showed that higher 25(OH)D levels were monotonically associated with a lower diabetes risk. This inverse association did not differ by sex, duration of follow-up, study sample size, diabetes diagnostic criteria, or 25(OH)D assay method. A linear trend analysis showed that each 10 nmol/L increment in 25(OH)D levels was associated with a 4% lower risk of type 2 diabetes (95% CI 3-6; P for linear trend , 0.0001). CONCLUSIONS-Our meta-analysis showed an inverse and significant association between circulating 25(OH)D levels and risk of type 2 diabetes across a broad range of blood 25(OH)D levels in diverse populations.

UR - http://www.scopus.com/inward/record.url?scp=84876809929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876809929&partnerID=8YFLogxK

U2 - 10.2337/dc12-0962

DO - 10.2337/dc12-0962

M3 - Article

C2 - 23613602

AN - SCOPUS:84876809929

VL - 36

SP - 1422

EP - 1428

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 5

ER -