Blood B-type natriuretic peptide and dialysis: Present assessment and future analyses

Mark Flemmer, Hussein Rajab, Tracy Mathena, James Paulson, Susan Perkins, Thomas Whelan, Ritche Chiu, Peter A. McCullough

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Brain natriuretic peptide (BNP) is elevated in hemodialysis (HD) patients and predicts increased mortality. Intra- and interdialytic changes in BNP have not been fully described.End-stage renal disease (ESRD) patients were prospectively recruited at three dialysis centers. At five visits, over a 6-week period, pre- and postdialysis BNP levels were measured. Pre- and postdialysis weights, blood pressure, fluid removed/given and demographic/medical information were recorded.Mean pre- and post-HD BNP (log-transformed) was not significantly different and did not correlate with fluid removed. Both pre- and post-HD BNP significantly decreased across the dialysis week (Pre-HD: intercept ≤ 2.69, slope ≤ '0.097, t ≤ '6.7, P <0.001) and across the five sessions (slope ≤ '0.046, t ≤ '2.47, P ≤ 0.01).Interdialytic BNP changes are not related to fluid removed. Chronic volume overload and increased left ventricular wall tension likely account for the BNP decrease across dialysis weeks and may be related to higher death rates among HD patients at the beginning of the week.

Original languageEnglish (US)
Pages (from-to)1094-1100
Number of pages7
JournalSouthern Medical Journal
Volume101
Issue number11
DOIs
StatePublished - Nov 2008
Externally publishedYes

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Brain Natriuretic Peptide
Dialysis
Renal Dialysis
Mortality
Chronic Kidney Failure
Demography
Blood Pressure
Weights and Measures

Keywords

  • B-type natriuretic peptide
  • End-stage renal disease
  • Hemodialysis
  • Left ventricular function

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Flemmer, M., Rajab, H., Mathena, T., Paulson, J., Perkins, S., Whelan, T., ... McCullough, P. A. (2008). Blood B-type natriuretic peptide and dialysis: Present assessment and future analyses. Southern Medical Journal, 101(11), 1094-1100. https://doi.org/10.1097/SMJ.0b013e318189aa56

Blood B-type natriuretic peptide and dialysis : Present assessment and future analyses. / Flemmer, Mark; Rajab, Hussein; Mathena, Tracy; Paulson, James; Perkins, Susan; Whelan, Thomas; Chiu, Ritche; McCullough, Peter A.

In: Southern Medical Journal, Vol. 101, No. 11, 11.2008, p. 1094-1100.

Research output: Contribution to journalArticle

Flemmer, M, Rajab, H, Mathena, T, Paulson, J, Perkins, S, Whelan, T, Chiu, R & McCullough, PA 2008, 'Blood B-type natriuretic peptide and dialysis: Present assessment and future analyses', Southern Medical Journal, vol. 101, no. 11, pp. 1094-1100. https://doi.org/10.1097/SMJ.0b013e318189aa56
Flemmer, Mark ; Rajab, Hussein ; Mathena, Tracy ; Paulson, James ; Perkins, Susan ; Whelan, Thomas ; Chiu, Ritche ; McCullough, Peter A. / Blood B-type natriuretic peptide and dialysis : Present assessment and future analyses. In: Southern Medical Journal. 2008 ; Vol. 101, No. 11. pp. 1094-1100.
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