Blood flow per unit retinal nerve fibre tissue volume is lower in the human inferior retina

Alon Harris, Y. Ishii, H. S. Chung, C. P. Jonescu-Cuypers, L. J. McCranor, L. Kagemann, H. J. Garzozi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Aim: To determine if perfusion per unit tissue volume of retinal nerve fibre layer and optic nerve head in the inferior sector is lower than in the superior sector. Methods: Heidelberg retinal tomogram (HRT) for topographic measurement of optic nerve head and retinal nerve fibre layer and Heidelberg retinal flowmeter (HRF) for retinal blood flow were performed on 19 normal healthy subjects. Measurements from the superior and inferior sectors were compared. The perfusion/nerve fibre ratio (PNR); the blood flow per unit retinal nerve fibre tissue volume, was calculated in each sector with a formula; HRF flow measurements divided by HRT measurements. Results: Retinal nerve fibre layer thickness in the inferior retina was significantly higher than in the superior retina (p<0.05). There were, however, no differences in retinal blood flow between the superior and inferior retinal sectors. The PNR in the inferior sector were significantly lower than in the superior sector (p=0.047 for HRF mean flow/rim volume and p = 0.0282 for HRF 75th percentile flow/rim volume). Conclusions: The inferior sector of retinal nerve fibre layer and optic nerve head may have lower blood flow per unit nerve tissue volume compared to the superior sector. This result suggests that the inferior sector is more vulnerable to elevated intraocular pressure (IOP) and ischaemic insults in glaucomatous optic neuropathy.

Original languageEnglish
Pages (from-to)184-188
Number of pages5
JournalBritish Journal of Ophthalmology
Volume87
Issue number2
DOIs
StatePublished - Feb 1 2003

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Nerve Tissue
Nerve Fibers
Retina
Flowmeters
Optic Disk
Perfusion
Optic Nerve Diseases
Intraocular Pressure
Healthy Volunteers

ASJC Scopus subject areas

  • Ophthalmology

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Harris, A., Ishii, Y., Chung, H. S., Jonescu-Cuypers, C. P., McCranor, L. J., Kagemann, L., & Garzozi, H. J. (2003). Blood flow per unit retinal nerve fibre tissue volume is lower in the human inferior retina. British Journal of Ophthalmology, 87(2), 184-188. https://doi.org/10.1136/bjo.87.2.184

Blood flow per unit retinal nerve fibre tissue volume is lower in the human inferior retina. / Harris, Alon; Ishii, Y.; Chung, H. S.; Jonescu-Cuypers, C. P.; McCranor, L. J.; Kagemann, L.; Garzozi, H. J.

In: British Journal of Ophthalmology, Vol. 87, No. 2, 01.02.2003, p. 184-188.

Research output: Contribution to journalArticle

Harris, A, Ishii, Y, Chung, HS, Jonescu-Cuypers, CP, McCranor, LJ, Kagemann, L & Garzozi, HJ 2003, 'Blood flow per unit retinal nerve fibre tissue volume is lower in the human inferior retina', British Journal of Ophthalmology, vol. 87, no. 2, pp. 184-188. https://doi.org/10.1136/bjo.87.2.184
Harris, Alon ; Ishii, Y. ; Chung, H. S. ; Jonescu-Cuypers, C. P. ; McCranor, L. J. ; Kagemann, L. ; Garzozi, H. J. / Blood flow per unit retinal nerve fibre tissue volume is lower in the human inferior retina. In: British Journal of Ophthalmology. 2003 ; Vol. 87, No. 2. pp. 184-188.
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