Blood flow switching among pulmonary capillaries is decreased during high hematocrit

William A. Baumgartner, Amanda J. Peterson, Robert G. Presson, Nobuhiro Tanabe, Eric M. Jaryszak, Wiltz W. Wagner

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Pulmonary capillary perfusion within a single alveolar wall continually switches among segments, even when large-vessel hemodynamics are constant. The mechanism is unknown. We hypothesize that the continually varying size of plasma gaps between individual red blood cells affects the likelihood of capillary segment closure and the probability of cells changing directions at the next capillary junction. We assumed that an increase in hematocrit would decrease the average distance between red blood cells, thereby decreasing the switching at each capillary junction. To test this idea, we observed 26 individual alveolar capillary networks by using videomicroscopy of excised canine lung lobes that were perfused first at normal hematocrit (31-43%) and then at increased hematocrit (51-62%). The number of switches decreased by 38% during increased hematocrit (P < 0.01). These results support the idea that a substantial part of flow switching among pulmonary capillaries is caused by the particulate nature of blood passing through a complex network of tubes with continuously varying hematocrit.

Original languageEnglish (US)
Pages (from-to)522-526
Number of pages5
JournalJournal of Applied Physiology
Volume97
Issue number2
DOIs
StatePublished - Aug 1 2004

Keywords

  • Dogs
  • Isolated canine lung lobes
  • Pulmonary capillary recruitment
  • Pulmonary microcirculation

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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