Blood island formation: Longstanding observations and modern interpretations

Michael J. Ferkowicz, Mervin Yoder

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

The yolk sac blood islands have long been recognized as the first site for blood cell emergence during embryonic development. Much of our understanding of how blood islands form is derived from studies conducted in chick embryos. Similar processes are thought to be active during murine blood island development. But, how strong is the evidence that the process of blood island formation in the chick coincides with that documented in the mouse? This review will discuss some of the principle studies that led to two widely accepted definitions of blood islands and will examine more recent studies performed in murine embryos to determine whether either of these popular definitions can be directly applied.

Original languageEnglish
Pages (from-to)1041-1047
Number of pages7
JournalExperimental Hematology
Volume33
Issue number9 SPEC. ISS.
DOIs
StatePublished - Sep 2005

Fingerprint

Yolk Sac
Chick Embryo
Embryonic Development
Blood Cells
Embryonic Structures

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

Cite this

Blood island formation : Longstanding observations and modern interpretations. / Ferkowicz, Michael J.; Yoder, Mervin.

In: Experimental Hematology, Vol. 33, No. 9 SPEC. ISS., 09.2005, p. 1041-1047.

Research output: Contribution to journalArticle

Ferkowicz, Michael J. ; Yoder, Mervin. / Blood island formation : Longstanding observations and modern interpretations. In: Experimental Hematology. 2005 ; Vol. 33, No. 9 SPEC. ISS. pp. 1041-1047.
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