Blood pressure regulation in ANF-transgenic mice: Role of angiotensin and vasopressin

B. Lichardus, A. T. Veress, Loren Field, H. Sonnenberg

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Transgenic mice overexpressing a transthyretin promoter-ANF structural fusion gene have a life-long reduction in arterial blood pressure compered to nontransgenic littermates. The present study was designed to test the hypothesis that the high plasma level of ANF in the transgenic mice inhibits the renin-angiotensin and/or vasopressin systems, thereby causing the hypotension. Mice were anaesthetized with Inactin and arterial pressure and heart rate were monitored before and during Saralasin infusion and vasopressin V1 receptor blockade. Effectiveness of the blockade was determined by injection of angiotensin and vasopressin before and during Saralasin and V1 receptor antagonist administration. Saralasin was associated with hypotension in both transgenic and nontransgenic mice. The decrease in blood pressure was proportionally greater in the transgenic animals. Vasopressin receptor blockade had little effect on blood pressure in either group. Heart rates were not different between the groups during any maneuver. We conclude that the chronic hypotensive effect of ANF overproduction does not involve the inhibition of either renin-angiotensin or vasopressin systems. The data, however, suggest that the renin-angiotensin system may be stimulated in the ANF-transgenic mice.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalPhysiological Research
Volume43
Issue number3
StatePublished - 1994
Externally publishedYes

Fingerprint

Vasopressin Receptors
Angiotensins
Atrial Natriuretic Factor
Saralasin
Vasopressins
Transgenic Mice
Blood Pressure
Renin
Hypotension
Arterial Pressure
Heart Rate
Genetically Modified Animals
Prealbumin
Gene Fusion
Renin-Angiotensin System
Injections

Keywords

  • atrial natriuretic factor
  • heart rate
  • hypotension
  • saralasin
  • vasopressin V receptor antagonist

ASJC Scopus subject areas

  • Physiology

Cite this

Blood pressure regulation in ANF-transgenic mice : Role of angiotensin and vasopressin. / Lichardus, B.; Veress, A. T.; Field, Loren; Sonnenberg, H.

In: Physiological Research, Vol. 43, No. 3, 1994, p. 145-150.

Research output: Contribution to journalArticle

Lichardus, B, Veress, AT, Field, L & Sonnenberg, H 1994, 'Blood pressure regulation in ANF-transgenic mice: Role of angiotensin and vasopressin', Physiological Research, vol. 43, no. 3, pp. 145-150.
Lichardus, B. ; Veress, A. T. ; Field, Loren ; Sonnenberg, H. / Blood pressure regulation in ANF-transgenic mice : Role of angiotensin and vasopressin. In: Physiological Research. 1994 ; Vol. 43, No. 3. pp. 145-150.
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