BOLD fMRI activation induced by vagus nerve stimulation in seizure patients

Wen Ching Liu, Kristine Mosier, A. J. Kalnin, D. Marks

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Objective: To identify the cerebral activated regions associated with the vagus nerve stimulation in epilepsy patients. Design: Blood oxygenation level dependent functional magnetic resonance imaging (BOLD fMRI) was employed to detect areas of the brain activated by vagus nerve stimulation in five patients with documented complex partial seizures. Methods: Functional MRI was done on a GE 1.5T Echospeed horizon scanner. Before each patient entered the scanner, the vagal nerve stimulator was set to a specific ON-OFF paradigm so that the data could be analysed using a box-car type of design. The brains were scanned both anatomically and functionally. The functional images were corrected for head motion and co-registered to the anatomical images. Maps of the activated areas were generated and analysed using the brain mapping software, SPM99. The threshold for activation was chosen as p

Original languageEnglish (US)
Pages (from-to)811-813
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume74
Issue number6
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

Fingerprint

Vagus Nerve Stimulation
Seizures
Magnetic Resonance Imaging
Brain Mapping
Brain
Epilepsy
Software
Head

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

BOLD fMRI activation induced by vagus nerve stimulation in seizure patients. / Liu, Wen Ching; Mosier, Kristine; Kalnin, A. J.; Marks, D.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 74, No. 6, 01.06.2003, p. 811-813.

Research output: Contribution to journalArticle

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