Bone adaptation to a mechanical loading program significantly increases skeletal fatigue resistance

Stuart J. Warden, Julie A. Hurst, Megan S. Sanders, Charles H. Turner, David Burr, Jiliang Li

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

Using a mechanical loading program to induce bone adaptation, we found that small (<2-fold) changes in the structural properties of the rat ulna increased its fatigue resistance >100-fold. This indicates that a moderate exercise program may be an effective preventative strategy for stress fractures. Introduction: There are currently limited preventative strategies for stress fractures. Because stress fracture risk is directly influenced by skeletal properties, it has been hypothesized that modification of these properties using a mechanical loading program may positively influence risk. The aim of this study was to investigate whether the bone changes associated with a mechanical loading program can enhance skeletal fatigue resistance. Materials and Methods: Site-specific mechanical loading was performed on one forearm of adult female Sprague-Dawley rats using the axial compression loading model. Loading was performed 3 days/week for 5 consecutive weeks to induce adaptation. The loaded and nonloaded ulnas in each animal were removed after the loading program, and their material and structural properties were determined. The ulna pairs were subsequently loaded until fatigue failure at the same constant peak axial load. Results: Mechanical loading induced consistent and predictable changes in the structural properties of loaded ulnas, with the largest change being a nearly 2-fold increase in midshaft minimum second moment of area (IMIN). The mechanical-loading induced bone changes resulted in a >100-fold increase in fatigue resistance in loaded ulnas, with resistance being exponentially related to the structural properties of the ulna. Conclusions: This study found that by enhancing the structural properties of a bone through a mechanical loading program, its fatigue resistance could be significantly improved. This indicates that an exercise program aimed at modifying bone structure may be used as a possible prevention strategy for stress fractures.

Original languageEnglish
Pages (from-to)809-816
Number of pages8
JournalJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume20
Issue number5
DOIs
StatePublished - May 2005

Fingerprint

Ulna
Stress Fractures
Fatigue
Bone and Bones
Weight-Bearing
Forearm
Sprague Dawley Rats

Keywords

  • Adaptation
  • Biomechanics
  • Exercise
  • Mechanical loading
  • Stress fractures

ASJC Scopus subject areas

  • Surgery

Cite this

Bone adaptation to a mechanical loading program significantly increases skeletal fatigue resistance. / Warden, Stuart J.; Hurst, Julie A.; Sanders, Megan S.; Turner, Charles H.; Burr, David; Li, Jiliang.

In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 20, No. 5, 05.2005, p. 809-816.

Research output: Contribution to journalArticle

Warden, Stuart J. ; Hurst, Julie A. ; Sanders, Megan S. ; Turner, Charles H. ; Burr, David ; Li, Jiliang. / Bone adaptation to a mechanical loading program significantly increases skeletal fatigue resistance. In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2005 ; Vol. 20, No. 5. pp. 809-816.
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