Bone and cartilage changes following experimental varus or valgus tibial angulation

D. D. Wu, David Burr, R. D. Boyd, E. L. Radin

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

The purpose of this work was to determine whether subchondral bone changes are an integral part of the development of osteoarthrosis of the knee following experimentally created tibial angulation. Thirty degree varus or valgus proximal tibial osteotomies were created in female New Zealand white rabbits. Bone and cartilage changes were assessed grossly, radiologically, and histologically. Thirty-four weeks following osteotomy, severe cartilage changes, including osteophytes, fibrillation, derangement of cell columns, and cloning, were evident on the overloaded condyle, accompanied by increased subchondral bone density. The pattern of cartilage deterioration was different from that found in other experimental, mechanically induced arthroses. We conclude that osteoarthrosis is a final common pathway for mechanically induced joint failure, and that progressive cartilage change is associated with increased subchondral bone density.

Original languageEnglish
Pages (from-to)572-585
Number of pages14
JournalJournal of Orthopaedic Research
Volume8
Issue number4
StatePublished - Jul 1990

Fingerprint

Cartilage
Bone and Bones
Osteotomy
Osteoarthritis
Bone Density
Osteophyte
Joint Diseases
Organism Cloning
Knee
Joints
Rabbits

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Wu, D. D., Burr, D., Boyd, R. D., & Radin, E. L. (1990). Bone and cartilage changes following experimental varus or valgus tibial angulation. Journal of Orthopaedic Research, 8(4), 572-585.

Bone and cartilage changes following experimental varus or valgus tibial angulation. / Wu, D. D.; Burr, David; Boyd, R. D.; Radin, E. L.

In: Journal of Orthopaedic Research, Vol. 8, No. 4, 07.1990, p. 572-585.

Research output: Contribution to journalArticle

Wu, DD, Burr, D, Boyd, RD & Radin, EL 1990, 'Bone and cartilage changes following experimental varus or valgus tibial angulation', Journal of Orthopaedic Research, vol. 8, no. 4, pp. 572-585.
Wu, D. D. ; Burr, David ; Boyd, R. D. ; Radin, E. L. / Bone and cartilage changes following experimental varus or valgus tibial angulation. In: Journal of Orthopaedic Research. 1990 ; Vol. 8, No. 4. pp. 572-585.
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