Bone and skeletal muscle

Key players in mechanotransduction and potential overlapping mechanisms

Craig A. Goodman, Troy A. Hornberger, Alexander Robling

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The development and maintenance of skeletal muscle and bone mass is critical for movement, health and issues associated with the quality of life. Skeletal muscle and bone mass are regulated by a variety of factors that include changes in mechanical loading. Moreover, bone mass is, in large part, regulated by muscle-derived mechanical forces and thus by changes in muscle mass/strength. A thorough understanding of the cellular mechanism(s) responsible for mechanotransduction in bone and skeletal muscle is essential for the development of effective exercise and pharmaceutical strategies aimed at increasing, and/or preventing the loss of, mass in these tissues. Thus, in this review we will attempt to summarize the current evidence for the major molecular mechanisms involved in mechanotransduction in skeletal muscle and bone. By examining the differences and similarities in mechanotransduction between these two tissues, it is hoped that this review will stimulate new insights and ideas for future research and promote collaboration between bone and muscle biologists.

Original languageEnglish (US)
Pages (from-to)24-36
Number of pages13
JournalBone
Volume80
DOIs
StatePublished - Nov 1 2015

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Skeletal Muscle
Bone and Bones
Muscles
Muscle Strength
Maintenance
Quality of Life
Health
Pharmaceutical Preparations

Keywords

  • Bone mineral density
  • Growth
  • Hypertrophy
  • Mechanical loading
  • MTORC1

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Histology

Cite this

Bone and skeletal muscle : Key players in mechanotransduction and potential overlapping mechanisms. / Goodman, Craig A.; Hornberger, Troy A.; Robling, Alexander.

In: Bone, Vol. 80, 01.11.2015, p. 24-36.

Research output: Contribution to journalArticle

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