Bone Density in Children with Single Ventricle Physiology

Edgard A. Bendaly, Linda DiMeglio, William F. Fadel, Roger A. Hurwitz

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Children with chronic diseases are at risk for low bone mineral density (BMD). There are no studies of BMD in children with congenital heart disease and particularly single ventricle (SV). Children with this defect are often treated with warfarin, suspected to negatively impact BMD in adults. We assessed BMD in patients with SV physiology and compared the BMD of subjects taking warfarin to those who were not. Subjects 5–12 years with SV were included. BMD z scores by dual-energy X-ray absorptiometry of the spine and total body less head (TBLH) were obtained. Calcium intake, activity level, height, and Tanner stage were assessed. Linear regression models and t tests were used to investigate differences between participants and normative data as well as between subjects’ subgroups. Twenty-six subjects were included and 16 took warfarin. Mean BMD z score at the spine was significantly lower than expected at −1.0 ± 0.2 (p 

Original languageEnglish (US)
Pages (from-to)779-785
Number of pages7
JournalPediatric Cardiology
Volume36
Issue number4
DOIs
StatePublished - 2015

Fingerprint

Bone Density
Warfarin
Linear Models
Spine
Photon Absorptiometry
Heart Diseases
Chronic Disease
Head
Calcium

Keywords

  • Anticoagulation
  • Bone health
  • Bone mineral density
  • Child health status
  • Congenital heart disease/defects

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Bone Density in Children with Single Ventricle Physiology. / Bendaly, Edgard A.; DiMeglio, Linda; Fadel, William F.; Hurwitz, Roger A.

In: Pediatric Cardiology, Vol. 36, No. 4, 2015, p. 779-785.

Research output: Contribution to journalArticle

Bendaly, Edgard A. ; DiMeglio, Linda ; Fadel, William F. ; Hurwitz, Roger A. / Bone Density in Children with Single Ventricle Physiology. In: Pediatric Cardiology. 2015 ; Vol. 36, No. 4. pp. 779-785.
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