Bone genes in the kidney of stone formers

Andrew Evan, Sharon B. Bledsoe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Intraoperative papillary biopsies from kidneys of idiopathic-calcium oxalate stone formers (ICSF) have revealed a distinct pattern of mineral deposition in the interstitium of the renal papilla. The earliest sites of these deposits, termed Randall's plaque, are found in the basement membrane of thin loops of Henle and appear to spread into the surrounding interstitium down to the papillary epithelium. Recent studies show kidney stones of ICSF patients grow attached to the renal papilla and at sites of Randall's plaque. Together these observations suggest that plaque formation may be the critical step in stone formation. In order to control plaque formation and thereby reduce future kidney stone development, the mechanism of plaque deposition must be understood. Because the renal papilla has unique anatomical features similar to bone and the fact that the interstitial deposits of ICSF patients are formed of biological apatite, this paper tests the hypothesis that sites of interstitial plaque form as a result of cell-mediated osteoblast-like activity.

Original languageEnglish
Title of host publicationAIP Conference Proceedings
Pages33-43
Number of pages11
Volume1049
DOIs
StatePublished - 2008
Event2nd International Urolithiasis Research Symposium - Indianapolis, IN, United States
Duration: Apr 17 2008Apr 18 2008

Other

Other2nd International Urolithiasis Research Symposium
CountryUnited States
CityIndianapolis, IN
Period4/17/084/18/08

Fingerprint

papillae
kidneys
genes
bones
oxalates
kidney stones
rocks
calcium
interstitials
deposits
osteoblasts
epithelium
apatites
basements
minerals
membranes
cells

Keywords

  • Biopsy tissue
  • Human stone formers
  • Osteoblast-like activity
  • Plaque
  • Protein matrix

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Evan, A., & Bledsoe, S. B. (2008). Bone genes in the kidney of stone formers. In AIP Conference Proceedings (Vol. 1049, pp. 33-43) https://doi.org/10.1063/1.2998053

Bone genes in the kidney of stone formers. / Evan, Andrew; Bledsoe, Sharon B.

AIP Conference Proceedings. Vol. 1049 2008. p. 33-43.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Evan, A & Bledsoe, SB 2008, Bone genes in the kidney of stone formers. in AIP Conference Proceedings. vol. 1049, pp. 33-43, 2nd International Urolithiasis Research Symposium, Indianapolis, IN, United States, 4/17/08. https://doi.org/10.1063/1.2998053
Evan A, Bledsoe SB. Bone genes in the kidney of stone formers. In AIP Conference Proceedings. Vol. 1049. 2008. p. 33-43 https://doi.org/10.1063/1.2998053
Evan, Andrew ; Bledsoe, Sharon B. / Bone genes in the kidney of stone formers. AIP Conference Proceedings. Vol. 1049 2008. pp. 33-43
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