Bone is Not Alone: the Effects of Skeletal Muscle Dysfunction in Chronic Kidney Disease

Keith G. Avin, Ranjani N. Moorthi

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Chronic kidney disease (CKD) is associated with a decline in muscle mass, strength, and function, collectively called “sarcopenia.” Sarcopenia is associated with hospitalizations and mortality in CKD and is therefore important to understand and characterize. While the focus of skeletal health in CKD has traditionally focused on bone and mineral aberrations, it is now recognized that sarcopenia must also play a role in poor musculoskeletal health in this population. In this paper, we present an overview of skeletal muscle changes in CKD, including defects in skeletal muscle catabolism and anabolism in uremic tissue. There are many gaps in knowledge in this field that should be the focus for future research to unravel pathogenesis and therapies for musculoskeletal health in CKD.

Original languageEnglish (US)
Pages (from-to)173-179
Number of pages7
JournalCurrent osteoporosis reports
Volume13
Issue number3
DOIs
StatePublished - Jun 1 2015

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Keywords

  • Atrophy
  • Myogenesis
  • Myostatin
  • Sarcopenia
  • Skeletal muscle

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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