Bone loss at the femoral neck in premenopausal white women

Effects of weight change and sex-hormone levels

Sex Hormone Levels, Siu Hui, Anthony J. Perkins, Lifen Zhou, Christopher Longcope, Michael Econs, Munro Peacock, Cindy McClintock, C. Conrad Johnston

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

To investigate whether bone loss occurs in the premenopause, we measured the bone mineral content (BMC), bone mineral density (BMD), and bone area in the spine (L2-L4), femoral neck, and total hip, as well as the sex hormone levels of 130 healthy premenopausal white women (age, 31-50 yr) at least three times over 1-9 yr. We found an increase in all three bone measurements at the spine but no change in volumetric density. Neither could we detect any age-related changes in any of the three measurements in the total hip. In contrast, we detected a significant decrease in femoral neck BMD over time, due to a decrease in BMC and increase in bone area. Greater loss in femoral neck BMD was associated independently with weight loss and lower levels of estrone sulfate or E2. Separating the women into those with FSH spikes (>20 IU/liter) and women with consistently low FSH, we found the latter group had smaller decrease in BMD and that the decrease was due less to a decline in BMC and more to an increase in bone area. In summary, femoral neck BMD decreases in premenopausal women, particularly those with lower levels of estrogens resulting from slowing ovarian function despite regular menses. This decrease can be offset by more rapid weight gain.

Original languageEnglish
Pages (from-to)1539-1543
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume87
Issue number4
DOIs
StatePublished - 2002

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Femur Neck
Gonadal Steroid Hormones
Bone Density
Bone
Weights and Measures
Bone and Bones
Minerals
Hip
Spine
Premenopause
Menstruation
Weight Gain
Weight Loss
Estrogens

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Bone loss at the femoral neck in premenopausal white women : Effects of weight change and sex-hormone levels. / Levels, Sex Hormone; Hui, Siu; Perkins, Anthony J.; Zhou, Lifen; Longcope, Christopher; Econs, Michael; Peacock, Munro; McClintock, Cindy; Conrad Johnston, C.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 87, No. 4, 2002, p. 1539-1543.

Research output: Contribution to journalArticle

Levels, Sex Hormone ; Hui, Siu ; Perkins, Anthony J. ; Zhou, Lifen ; Longcope, Christopher ; Econs, Michael ; Peacock, Munro ; McClintock, Cindy ; Conrad Johnston, C. / Bone loss at the femoral neck in premenopausal white women : Effects of weight change and sex-hormone levels. In: Journal of Clinical Endocrinology and Metabolism. 2002 ; Vol. 87, No. 4. pp. 1539-1543.
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