Bone marrow scanning in Paget's disease

J. W. Fletcher, R. L. Butler, R. E. Henry, E. Solaric-George, R. M. Donati

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Four patients with Paget's disease of the bone were studied with bone marrow reticuloendothelial space scanning using 99Tc(m) sulfur colloid. All the patients demonstrated focal areas of decreased concentration of the radiocolloid material that corresponded anatomically to radiographic evidence of Paget's disease. Three patients were found to have focal areas of decreased to absent concentration of the radiocolloid material that corresponded anatomically to areas of increased 99Tc(m) polyphosphate or 18F uptake on bone scans. Possible mechanisms to explain these focal areas of apparently decreased reticuloendothelial activity are discussed and may include focal marrow replacement or focal arteriovenous shunting. These results would suggest that Paget's disease should be considered as a diagnostic possibility when focal areas of diminished reticuloendothelial activity are observed in bone marrow scanning with radiocolloid material.

Original languageEnglish (US)
Pages (from-to)928-939
Number of pages12
JournalJournal of Nuclear Medicine
Issue number12
StatePublished - Dec 1 1973
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Fletcher, J. W., Butler, R. L., Henry, R. E., Solaric-George, E., & Donati, R. M. (1973). Bone marrow scanning in Paget's disease. Journal of Nuclear Medicine, 14(12), 928-939.