Bone metabolism in children with human immunodeficiency virus infection receiving highly active anti-retroviral therapy including a protease inhibitor

Belen M. Tan, Robert P. Nelson, Michelle James-Yarish, Patricia J. Emmanuel, Scott J. Schurman

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26 Scopus citations

Abstract

We measured serum osteocalcin levels in prepubertal children with human immunodeficiency virus (HIV) infection receiving highly active antiretroviral therapy including a protease inhibitor and uninfected control children. Osteocalcin values were significantly elevated in the HIV-infected patients. Though osteocalcin serves as an index of bone formation, it likely functions as a negative regulator of bone formation. Further study is necessary to determine whether protease inhibitors normalize bone physiology or decrease bone formation and reduce bone mineral density in children receiving these therapies.

Original languageEnglish (US)
Pages (from-to)447-451
Number of pages5
JournalJournal of Pediatrics
Volume139
Issue number3
DOIs
StatePublished - Jan 1 2001

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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