Bone microdamage and skeletal fragility in osteoporotic and stress fractures

David Burr, Mark R. Forwood, David P. Fyhrie, R. Bruce Martin, Mitchell B. Schaffler, Charles H. Turner

Research output: Contribution to journalArticle

504 Citations (Scopus)

Abstract

The accumulation of bone microdamage has been proposed as one factor that contributes to increased skeletal fragility with age and that may increase the risk for fracture in older women. This paper reviews the current status and understanding of microdamage physiology and its importance to skeletal fragility. Several questions are addressed: Does microdamage exist in vivo in bone? If it does, does it impair bone quality? Does microdamage accumulate with age, and is the accumulation of damage with age sufficient to cause a fracture? The nature of the damage repair mechanism is reviewed, and it is proposed that osteoporotic fracture may be a consequence of a positive feedback between damage accumulation and the increased remodeling space associated with repair.

Original languageEnglish
Pages (from-to)6-15
Number of pages10
JournalJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume12
Issue number1
DOIs
StatePublished - 1997

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Stress Fractures
Osteoporotic Fractures
Bone and Bones

ASJC Scopus subject areas

  • Surgery

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Bone microdamage and skeletal fragility in osteoporotic and stress fractures. / Burr, David; Forwood, Mark R.; Fyhrie, David P.; Martin, R. Bruce; Schaffler, Mitchell B.; Turner, Charles H.

In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 12, No. 1, 1997, p. 6-15.

Research output: Contribution to journalArticle

Burr, David ; Forwood, Mark R. ; Fyhrie, David P. ; Martin, R. Bruce ; Schaffler, Mitchell B. ; Turner, Charles H. / Bone microdamage and skeletal fragility in osteoporotic and stress fractures. In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 1997 ; Vol. 12, No. 1. pp. 6-15.
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