Bone Modeling and Remodeling

Matthew R. Allen, David B. Burr

Research output: Chapter in Book/Report/Conference proceedingChapter

26 Scopus citations

Abstract

Bone is a dynamic tissue that is constantly adapting its structure. It is initially formed during development through either an intramembranous or endochondral ossification process. Once formed, the bone grows and changes shape by modeling, a process in which either bone formation or bone resorption occurs on a given bone surface. Bone remodeling functions to renew the skeleton and involves sequential bone resorption and formation at the same spatial location. Both processes affect overall bone structure, while remodeling affects material properties such as microdamage, mineralization, and collagen cross-linking. The clinical assessment of bone formation and resorption can be made through the histologic assessment of bone biopsies or through the more common use of serum or urine biomarkers.

Original languageEnglish (US)
Title of host publicationBasic and Applied Bone Biology
PublisherElsevier Inc.
Pages75-90
Number of pages16
ISBN (Print)9780124160156
DOIs
StatePublished - Aug 12 2013

    Fingerprint

Keywords

  • Basic multicellular unit
  • Development
  • Endochondral ossification
  • Growth
  • Intramembranous ossification
  • Remodeling cycle

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)

Cite this

Allen, M. R., & Burr, D. B. (2013). Bone Modeling and Remodeling. In Basic and Applied Bone Biology (pp. 75-90). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-416015-6.00004-6