Bone Modeling and Remodeling

Matthew R. Allen; David B. Burr

doi:10.1016/B978-0-12-416015-6.00004-6

Bone Modeling and Remodeling

Matthew R. Allen, David B. Burr

Anatomy & Cell Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

31 Scopus citations

Abstract

Bone is a dynamic tissue that is constantly adapting its structure. It is initially formed during development through either an intramembranous or endochondral ossification process. Once formed, the bone grows and changes shape by modeling, a process in which either bone formation or bone resorption occurs on a given bone surface. Bone remodeling functions to renew the skeleton and involves sequential bone resorption and formation at the same spatial location. Both processes affect overall bone structure, while remodeling affects material properties such as microdamage, mineralization, and collagen cross-linking. The clinical assessment of bone formation and resorption can be made through the histologic assessment of bone biopsies or through the more common use of serum or urine biomarkers.

Original language	English (US)
Title of host publication	Basic and Applied Bone Biology
Publisher	Elsevier Inc.
Pages	75-90
Number of pages	16
ISBN (Print)	9780124160156
DOIs	https://doi.org/10.1016/B978-0-12-416015-6.00004-6
State	Published - Aug 12 2013

Keywords

Basic multicellular unit
Development
Endochondral ossification
Growth
Intramembranous ossification
Remodeling cycle

ASJC Scopus subject areas

Medicine(all)
Dentistry(all)

Access to Document

10.1016/B978-0-12-416015-6.00004-6

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Allen, M. R., & Burr, D. B. (2013). Bone Modeling and Remodeling. In Basic and Applied Bone Biology (pp. 75-90). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-416015-6.00004-6

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