Abstract
Bone is a dynamic tissue that is constantly adapting its structure. It is initially formed during development through either an intramembranous or endochondral ossification process. Once formed, the bone grows and changes shape by modeling, a process in which either bone formation or bone resorption occurs on a given bone surface. Bone remodeling functions to renew the skeleton and involves sequential bone resorption and formation at the same spatial location. Both processes affect overall bone structure, while remodeling affects material properties such as microdamage, mineralization, and collagen cross-linking. The clinical assessment of bone formation and resorption can be made through the histologic assessment of bone biopsies or through the more common use of serum or urine biomarkers.
| Original language | English |
|---|---|
| Title of host publication | Basic and Applied Bone Biology |
| Publisher | Elsevier Inc. |
| Pages | 75-90 |
| Number of pages | 16 |
| ISBN (Print) | 9780124160156 |
| DOIs | |
| State | Published - Aug 12 2013 |
Fingerprint
Keywords
- Basic multicellular unit
- Development
- Endochondral ossification
- Growth
- Intramembranous ossification
- Remodeling cycle
ASJC Scopus subject areas
- Medicine(all)
- Dentistry(all)
Cite this
Bone Modeling and Remodeling. / Allen, Matthew; Burr, David.
Basic and Applied Bone Biology. Elsevier Inc., 2013. p. 75-90.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Bone Modeling and Remodeling
AU - Allen, Matthew
AU - Burr, David
PY - 2013/8/12
Y1 - 2013/8/12
N2 - Bone is a dynamic tissue that is constantly adapting its structure. It is initially formed during development through either an intramembranous or endochondral ossification process. Once formed, the bone grows and changes shape by modeling, a process in which either bone formation or bone resorption occurs on a given bone surface. Bone remodeling functions to renew the skeleton and involves sequential bone resorption and formation at the same spatial location. Both processes affect overall bone structure, while remodeling affects material properties such as microdamage, mineralization, and collagen cross-linking. The clinical assessment of bone formation and resorption can be made through the histologic assessment of bone biopsies or through the more common use of serum or urine biomarkers.
AB - Bone is a dynamic tissue that is constantly adapting its structure. It is initially formed during development through either an intramembranous or endochondral ossification process. Once formed, the bone grows and changes shape by modeling, a process in which either bone formation or bone resorption occurs on a given bone surface. Bone remodeling functions to renew the skeleton and involves sequential bone resorption and formation at the same spatial location. Both processes affect overall bone structure, while remodeling affects material properties such as microdamage, mineralization, and collagen cross-linking. The clinical assessment of bone formation and resorption can be made through the histologic assessment of bone biopsies or through the more common use of serum or urine biomarkers.
KW - Basic multicellular unit
KW - Development
KW - Endochondral ossification
KW - Growth
KW - Intramembranous ossification
KW - Remodeling cycle
UR - http://www.scopus.com/inward/record.url?scp=84902064432&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902064432&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-416015-6.00004-6
DO - 10.1016/B978-0-12-416015-6.00004-6
M3 - Chapter
AN - SCOPUS:84902064432
SN - 9780124160156
SP - 75
EP - 90
BT - Basic and Applied Bone Biology
PB - Elsevier Inc.
ER -