Brain choline in depression: In vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy

H. Cecil Charles, Francois Lazeyras, K. Ranga Rama Krishnan, Orest B. Boyko, Martha Payne, Debbie Moore

Research output: Contribution to journalArticle

102 Scopus citations


1. Seven subjects with depression and matched controls were studied using proton spectroscopy to test the hypothesis that choline will be elevated in depression. 2. The proton spectroscopy was repeated after recovery from depression. 3. The study confirmed a state dependent increase in choline in the brain. 4. This change may be used as an in vivo marker of change in depression.

Original languageEnglish (US)
Pages (from-to)1121-1127
Number of pages7
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Issue number7
StatePublished - Nov 1994



  • N-acetyl aspartate
  • choline
  • cholinergic system
  • magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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