Brain choline in depression: In vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy

H. Cecil Charles, Francois Lazeyras, K. Ranga Rama Krishnan, Orest Boyko, Martha Payne, Debbie Moore

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

1. Seven subjects with depression and matched controls were studied using proton spectroscopy to test the hypothesis that choline will be elevated in depression. 2. The proton spectroscopy was repeated after recovery from depression. 3. The study confirmed a state dependent increase in choline in the brain. 4. This change may be used as an in vivo marker of change in depression.

Original languageEnglish (US)
Pages (from-to)1121-1127
Number of pages7
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume18
Issue number7
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Choline
Antidepressive Agents
Protons
Hydrogen
Spectrum Analysis
Brain
Therapeutics

Keywords

  • choline
  • cholinergic system
  • magnetic resonance spectroscopy
  • N-acetyl aspartate

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Brain choline in depression : In vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy. / Charles, H. Cecil; Lazeyras, Francois; Krishnan, K. Ranga Rama; Boyko, Orest; Payne, Martha; Moore, Debbie.

In: Progress in Neuropsychopharmacology and Biological Psychiatry, Vol. 18, No. 7, 1994, p. 1121-1127.

Research output: Contribution to journalArticle

Charles, H. Cecil ; Lazeyras, Francois ; Krishnan, K. Ranga Rama ; Boyko, Orest ; Payne, Martha ; Moore, Debbie. / Brain choline in depression : In vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy. In: Progress in Neuropsychopharmacology and Biological Psychiatry. 1994 ; Vol. 18, No. 7. pp. 1121-1127.
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