Brain cortical structural differences between non-central nervous system cancer patients treated with and without chemotherapy compared to non-cancer controls

A cross-sectional pilot MRI study using clinically indicated scans

Mark S. Shiroishi, Vikash Gupta, Bavrina Bigjahan, Steven Y. Cen, Faisal Rashid, Darryl H. Hwang, Alexander Lerner, Orest Boyko, Chia Shang Jason Liu, Meng Law, Paul M. Thompson, Neda Jahanshad

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Background: Increases in cancer survival have made understanding the basis of cancer-related cognitive impairment (CRCI) more important. CRCI neuroimaging studies have traditionally used dedicated research brain MRIs in breast cancer survivors with small sample sizes; little is known about other non-CNS cancers. However, there is a wealth of unused data from clinically-indicated MRIs that could be used to study CRCI. Objective: Evaluate brain cortical structural differences in those with non-CNS cancers using clinically-indicated MRIs. Design: Cross-sectional Patients: Adult non-CNS cancer and non-cancer control (C) patients who underwent clinically-indicated MRIs. Methods: Brain cortical surface area and thickness were measured using 3D T1-weighted images. An age-adjusted linear regression model was used and the Benjamini and Hochberg false discovery rate (FDR) corrected for multiple comparisons. Group comparisons were: cancer cases with chemotherapy (Ch+), cancer cases without chemotherapy (Ch-) and subgroup of lung cancer cases with and without chemotherapy vs C. Results: Sixty-four subjects were analyzed: 22 Ch+, 23 Ch- and 19 C patients. Subgroup analysis of 16 LCa was also performed. Statistically significant decreases in either cortical surface area or thickness were found in multiple ROIs primarily within the frontal and temporal lobes for all comparisons. Limitations: Several limitations were apparent including a small sample size that precluded adjustment for other covariates. Conclusions: Our preliminary results suggest that various types of non-CNS cancers, both with and without chemotherapy, may result in brain structural abnormalities. Also, there is a wealth of untapped clinical MRIs that could be used for future CRCI studies.

Original languageEnglish (US)
Title of host publication13th International Conference on Medical Information Processing and Analysis
PublisherSPIE
Volume10572
ISBN (Electronic)9781510616332
DOIs
StatePublished - Jan 1 2017
Externally publishedYes
Event13th International Conference on Medical Information Processing and Analysis, SIPAIM 2017 - San Andres Island, Colombia
Duration: Oct 5 2017Oct 7 2017

Other

Other13th International Conference on Medical Information Processing and Analysis, SIPAIM 2017
CountryColombia
CitySan Andres Island
Period10/5/1710/7/17

Fingerprint

nervous system
Chemotherapy
Neurology
chemotherapy
Magnetic resonance imaging
brain
Brain
Cancer
cancer
impairment
Neuroimaging
Small Sample Size
Linear regression
Surface area
subgroups
Subgroup
Multiple Comparisons
Lung Cancer
Linear Regression Model
Breast Cancer

Keywords

  • Cancer-related cognitive impairment (CRCI)
  • chemobrain
  • chemotherapy
  • cognition
  • complications and late effects of therapy
  • psychological/behavioral oncology
  • structural MRI

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Shiroishi, M. S., Gupta, V., Bigjahan, B., Cen, S. Y., Rashid, F., Hwang, D. H., ... Jahanshad, N. (2017). Brain cortical structural differences between non-central nervous system cancer patients treated with and without chemotherapy compared to non-cancer controls: A cross-sectional pilot MRI study using clinically indicated scans. In 13th International Conference on Medical Information Processing and Analysis (Vol. 10572). [105720G] SPIE. https://doi.org/10.1117/12.2285971

Brain cortical structural differences between non-central nervous system cancer patients treated with and without chemotherapy compared to non-cancer controls : A cross-sectional pilot MRI study using clinically indicated scans. / Shiroishi, Mark S.; Gupta, Vikash; Bigjahan, Bavrina; Cen, Steven Y.; Rashid, Faisal; Hwang, Darryl H.; Lerner, Alexander; Boyko, Orest; Liu, Chia Shang Jason; Law, Meng; Thompson, Paul M.; Jahanshad, Neda.

13th International Conference on Medical Information Processing and Analysis. Vol. 10572 SPIE, 2017. 105720G.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shiroishi, MS, Gupta, V, Bigjahan, B, Cen, SY, Rashid, F, Hwang, DH, Lerner, A, Boyko, O, Liu, CSJ, Law, M, Thompson, PM & Jahanshad, N 2017, Brain cortical structural differences between non-central nervous system cancer patients treated with and without chemotherapy compared to non-cancer controls: A cross-sectional pilot MRI study using clinically indicated scans. in 13th International Conference on Medical Information Processing and Analysis. vol. 10572, 105720G, SPIE, 13th International Conference on Medical Information Processing and Analysis, SIPAIM 2017, San Andres Island, Colombia, 10/5/17. https://doi.org/10.1117/12.2285971
Shiroishi MS, Gupta V, Bigjahan B, Cen SY, Rashid F, Hwang DH et al. Brain cortical structural differences between non-central nervous system cancer patients treated with and without chemotherapy compared to non-cancer controls: A cross-sectional pilot MRI study using clinically indicated scans. In 13th International Conference on Medical Information Processing and Analysis. Vol. 10572. SPIE. 2017. 105720G https://doi.org/10.1117/12.2285971
Shiroishi, Mark S. ; Gupta, Vikash ; Bigjahan, Bavrina ; Cen, Steven Y. ; Rashid, Faisal ; Hwang, Darryl H. ; Lerner, Alexander ; Boyko, Orest ; Liu, Chia Shang Jason ; Law, Meng ; Thompson, Paul M. ; Jahanshad, Neda. / Brain cortical structural differences between non-central nervous system cancer patients treated with and without chemotherapy compared to non-cancer controls : A cross-sectional pilot MRI study using clinically indicated scans. 13th International Conference on Medical Information Processing and Analysis. Vol. 10572 SPIE, 2017.
@inproceedings{48e018e7b4514971bd0289b3934d95cc,
title = "Brain cortical structural differences between non-central nervous system cancer patients treated with and without chemotherapy compared to non-cancer controls: A cross-sectional pilot MRI study using clinically indicated scans",
abstract = "Background: Increases in cancer survival have made understanding the basis of cancer-related cognitive impairment (CRCI) more important. CRCI neuroimaging studies have traditionally used dedicated research brain MRIs in breast cancer survivors with small sample sizes; little is known about other non-CNS cancers. However, there is a wealth of unused data from clinically-indicated MRIs that could be used to study CRCI. Objective: Evaluate brain cortical structural differences in those with non-CNS cancers using clinically-indicated MRIs. Design: Cross-sectional Patients: Adult non-CNS cancer and non-cancer control (C) patients who underwent clinically-indicated MRIs. Methods: Brain cortical surface area and thickness were measured using 3D T1-weighted images. An age-adjusted linear regression model was used and the Benjamini and Hochberg false discovery rate (FDR) corrected for multiple comparisons. Group comparisons were: cancer cases with chemotherapy (Ch+), cancer cases without chemotherapy (Ch-) and subgroup of lung cancer cases with and without chemotherapy vs C. Results: Sixty-four subjects were analyzed: 22 Ch+, 23 Ch- and 19 C patients. Subgroup analysis of 16 LCa was also performed. Statistically significant decreases in either cortical surface area or thickness were found in multiple ROIs primarily within the frontal and temporal lobes for all comparisons. Limitations: Several limitations were apparent including a small sample size that precluded adjustment for other covariates. Conclusions: Our preliminary results suggest that various types of non-CNS cancers, both with and without chemotherapy, may result in brain structural abnormalities. Also, there is a wealth of untapped clinical MRIs that could be used for future CRCI studies.",
keywords = "Cancer-related cognitive impairment (CRCI), chemobrain, chemotherapy, cognition, complications and late effects of therapy, psychological/behavioral oncology, structural MRI",
author = "Shiroishi, {Mark S.} and Vikash Gupta and Bavrina Bigjahan and Cen, {Steven Y.} and Faisal Rashid and Hwang, {Darryl H.} and Alexander Lerner and Orest Boyko and Liu, {Chia Shang Jason} and Meng Law and Thompson, {Paul M.} and Neda Jahanshad",
year = "2017",
month = "1",
day = "1",
doi = "10.1117/12.2285971",
language = "English (US)",
volume = "10572",
booktitle = "13th International Conference on Medical Information Processing and Analysis",
publisher = "SPIE",

}

TY - GEN

T1 - Brain cortical structural differences between non-central nervous system cancer patients treated with and without chemotherapy compared to non-cancer controls

T2 - A cross-sectional pilot MRI study using clinically indicated scans

AU - Shiroishi, Mark S.

AU - Gupta, Vikash

AU - Bigjahan, Bavrina

AU - Cen, Steven Y.

AU - Rashid, Faisal

AU - Hwang, Darryl H.

AU - Lerner, Alexander

AU - Boyko, Orest

AU - Liu, Chia Shang Jason

AU - Law, Meng

AU - Thompson, Paul M.

AU - Jahanshad, Neda

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Increases in cancer survival have made understanding the basis of cancer-related cognitive impairment (CRCI) more important. CRCI neuroimaging studies have traditionally used dedicated research brain MRIs in breast cancer survivors with small sample sizes; little is known about other non-CNS cancers. However, there is a wealth of unused data from clinically-indicated MRIs that could be used to study CRCI. Objective: Evaluate brain cortical structural differences in those with non-CNS cancers using clinically-indicated MRIs. Design: Cross-sectional Patients: Adult non-CNS cancer and non-cancer control (C) patients who underwent clinically-indicated MRIs. Methods: Brain cortical surface area and thickness were measured using 3D T1-weighted images. An age-adjusted linear regression model was used and the Benjamini and Hochberg false discovery rate (FDR) corrected for multiple comparisons. Group comparisons were: cancer cases with chemotherapy (Ch+), cancer cases without chemotherapy (Ch-) and subgroup of lung cancer cases with and without chemotherapy vs C. Results: Sixty-four subjects were analyzed: 22 Ch+, 23 Ch- and 19 C patients. Subgroup analysis of 16 LCa was also performed. Statistically significant decreases in either cortical surface area or thickness were found in multiple ROIs primarily within the frontal and temporal lobes for all comparisons. Limitations: Several limitations were apparent including a small sample size that precluded adjustment for other covariates. Conclusions: Our preliminary results suggest that various types of non-CNS cancers, both with and without chemotherapy, may result in brain structural abnormalities. Also, there is a wealth of untapped clinical MRIs that could be used for future CRCI studies.

AB - Background: Increases in cancer survival have made understanding the basis of cancer-related cognitive impairment (CRCI) more important. CRCI neuroimaging studies have traditionally used dedicated research brain MRIs in breast cancer survivors with small sample sizes; little is known about other non-CNS cancers. However, there is a wealth of unused data from clinically-indicated MRIs that could be used to study CRCI. Objective: Evaluate brain cortical structural differences in those with non-CNS cancers using clinically-indicated MRIs. Design: Cross-sectional Patients: Adult non-CNS cancer and non-cancer control (C) patients who underwent clinically-indicated MRIs. Methods: Brain cortical surface area and thickness were measured using 3D T1-weighted images. An age-adjusted linear regression model was used and the Benjamini and Hochberg false discovery rate (FDR) corrected for multiple comparisons. Group comparisons were: cancer cases with chemotherapy (Ch+), cancer cases without chemotherapy (Ch-) and subgroup of lung cancer cases with and without chemotherapy vs C. Results: Sixty-four subjects were analyzed: 22 Ch+, 23 Ch- and 19 C patients. Subgroup analysis of 16 LCa was also performed. Statistically significant decreases in either cortical surface area or thickness were found in multiple ROIs primarily within the frontal and temporal lobes for all comparisons. Limitations: Several limitations were apparent including a small sample size that precluded adjustment for other covariates. Conclusions: Our preliminary results suggest that various types of non-CNS cancers, both with and without chemotherapy, may result in brain structural abnormalities. Also, there is a wealth of untapped clinical MRIs that could be used for future CRCI studies.

KW - Cancer-related cognitive impairment (CRCI)

KW - chemobrain

KW - chemotherapy

KW - cognition

KW - complications and late effects of therapy

KW - psychological/behavioral oncology

KW - structural MRI

UR - http://www.scopus.com/inward/record.url?scp=85038442734&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85038442734&partnerID=8YFLogxK

U2 - 10.1117/12.2285971

DO - 10.1117/12.2285971

M3 - Conference contribution

VL - 10572

BT - 13th International Conference on Medical Information Processing and Analysis

PB - SPIE

ER -