Brain Imaging Genomics: Integrated Analysis and Machine Learning

Li Shen, Paul M. Thompson

Research output: Contribution to journalArticle


Brain imaging genomics is an emerging data science field, where integrated analysis of brain imaging and genomics data, often combined with other biomarker, clinical, and environmental data, is performed to gain new insights into the phenotypic, genetic, and molecular characteristics of the brain as well as their impact on normal and disordered brain function and behavior. It has enormous potential to contribute significantly to biomedical discoveries in brain science. Given the increasingly important role of statistical and machine learning in biomedicine and rapidly growing literature in brain imaging genomics, we provide an up-to-date and comprehensive review of statistical and machine learning methods for brain imaging genomics, as well as a practical discussion on method selection for various biomedical applications.

Original languageEnglish (US)
Article number8886705
Pages (from-to)125-162
Number of pages38
JournalProceedings of the IEEE
Issue number1
StatePublished - Jan 2020
Externally publishedYes


  • Big data
  • brain imaging
  • genomics
  • machine learning
  • statistics

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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