Brain metastases in disseminated germinal neoplasms. Incidence and clinical course

Stephen D. Williams, Lawrence H. Einhorn

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

From July 1973, to March 1978, 139 patients with disseminated germinal neoplasms were treated with a variety of combination chemotherapy regimens. Twenty-one patients (15.1%) exhibited evidence of brain metastases at some time during their course. Central nervous system spread occurred somewhat more frequently in patients with choriocarcinoma and yolk sac histologies, although all types were at risk. This was a major cause of morbidity and patients with sytemic relapse and thus did not affect overall survival. We have yet to identify a subgroup who potentially could benefit from prophylactic central nervous system therapy.

Original languageEnglish (US)
Pages (from-to)1514-1516
Number of pages3
JournalCancer
Volume44
Issue number4
DOIs
StatePublished - Oct 1979

Fingerprint

Neoplasm Metastasis
Incidence
Brain
Neoplasms
Central Nervous System
Yolk Sac
Choriocarcinoma
Combination Drug Therapy
Histology
Morbidity
Recurrence
Survival
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Brain metastases in disseminated germinal neoplasms. Incidence and clinical course. / Williams, Stephen D.; Einhorn, Lawrence H.

In: Cancer, Vol. 44, No. 4, 10.1979, p. 1514-1516.

Research output: Contribution to journalArticle

@article{1147d7ec4cf94069a3767240387b7bb4,
title = "Brain metastases in disseminated germinal neoplasms. Incidence and clinical course",
abstract = "From July 1973, to March 1978, 139 patients with disseminated germinal neoplasms were treated with a variety of combination chemotherapy regimens. Twenty-one patients (15.1{\%}) exhibited evidence of brain metastases at some time during their course. Central nervous system spread occurred somewhat more frequently in patients with choriocarcinoma and yolk sac histologies, although all types were at risk. This was a major cause of morbidity and patients with sytemic relapse and thus did not affect overall survival. We have yet to identify a subgroup who potentially could benefit from prophylactic central nervous system therapy.",
author = "Williams, {Stephen D.} and Einhorn, {Lawrence H.}",
year = "1979",
month = "10",
doi = "10.1002/1097-0142(197910)44:4<1514::AID-CNCR2820440450>3.0.CO;2-4",
language = "English (US)",
volume = "44",
pages = "1514--1516",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Brain metastases in disseminated germinal neoplasms. Incidence and clinical course

AU - Williams, Stephen D.

AU - Einhorn, Lawrence H.

PY - 1979/10

Y1 - 1979/10

N2 - From July 1973, to March 1978, 139 patients with disseminated germinal neoplasms were treated with a variety of combination chemotherapy regimens. Twenty-one patients (15.1%) exhibited evidence of brain metastases at some time during their course. Central nervous system spread occurred somewhat more frequently in patients with choriocarcinoma and yolk sac histologies, although all types were at risk. This was a major cause of morbidity and patients with sytemic relapse and thus did not affect overall survival. We have yet to identify a subgroup who potentially could benefit from prophylactic central nervous system therapy.

AB - From July 1973, to March 1978, 139 patients with disseminated germinal neoplasms were treated with a variety of combination chemotherapy regimens. Twenty-one patients (15.1%) exhibited evidence of brain metastases at some time during their course. Central nervous system spread occurred somewhat more frequently in patients with choriocarcinoma and yolk sac histologies, although all types were at risk. This was a major cause of morbidity and patients with sytemic relapse and thus did not affect overall survival. We have yet to identify a subgroup who potentially could benefit from prophylactic central nervous system therapy.

UR - http://www.scopus.com/inward/record.url?scp=0018596305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018596305&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(197910)44:4<1514::AID-CNCR2820440450>3.0.CO;2-4

DO - 10.1002/1097-0142(197910)44:4<1514::AID-CNCR2820440450>3.0.CO;2-4

M3 - Article

C2 - 227567

AN - SCOPUS:0018596305

VL - 44

SP - 1514

EP - 1516

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 4

ER -