Brain metastases in disseminated germinal neoplasms. Incidence and clinical course

Stephen D. Williams, Lawrence H. Einhorn

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

From July 1973, to March 1978, 139 patients with disseminated germinal neoplasms were treated with a variety of combination chemotherapy regimens. Twenty-one patients (15.1%) exhibited evidence of brain metastases at some time during their course. Central nervous system spread occurred somewhat more frequently in patients with choriocarcinoma and yolk sac histologies, although all types were at risk. This was a major cause of morbidity and patients with sytemic relapse and thus did not affect overall survival. We have yet to identify a subgroup who potentially could benefit from prophylactic central nervous system therapy.

Original languageEnglish (US)
Pages (from-to)1514-1516
Number of pages3
JournalCancer
Volume44
Issue number4
DOIs
StatePublished - Oct 1979

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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