Brain natriuretic peptides: Differential localization of a new family of neuropeptides

Clifford B. Saper, Karen M. Hurley, Margaret M. Moga, H. Rodney Holmes, Steven A. Adams, Kathleen M. Leahy, Philip Needleman

Research output: Contribution to journalArticlepeer-review

95 Scopus citations


Brain natriuretic peptide (BNP) is a recently discovered neuropeptide, isolated from the porcine brian, that is highly homologous to atriopeptin (AP), the atrial natriuretic peptide. We used a set of highly selective antisera against the two peptides to map their differential distribution immunohistochemically in the rat central nervous system. BNP immunoreactivity has a distinct distribution, involving many central autonomic and endocrine control structures that contain little if any AP immunoreactivity. AP and BNP belong to a family of neuropeptides that may be important in central cardiovascular control.

Original languageEnglish (US)
Pages (from-to)29-34
Number of pages6
JournalNeuroscience Letters
Issue number1
StatePublished - Jan 2 1989
Externally publishedYes


  • Atrial natriuretic peptide
  • Brain natriuretic peptide
  • Circumventricular organ
  • Nucleus of the solitary tract
  • Vasopressin neuron

ASJC Scopus subject areas

  • Neuroscience(all)

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