Brain natriuretic peptides

Differential localization of a new family of neuropeptides

Clifford B. Saper, Karen M. Hurley, Margaret Moga, H. Rodney Holmes, Steven A. Adams, Kathleen M. Leahy, Philip Needleman

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Brain natriuretic peptide (BNP) is a recently discovered neuropeptide, isolated from the porcine brian, that is highly homologous to atriopeptin (AP), the atrial natriuretic peptide. We used a set of highly selective antisera against the two peptides to map their differential distribution immunohistochemically in the rat central nervous system. BNP immunoreactivity has a distinct distribution, involving many central autonomic and endocrine control structures that contain little if any AP immunoreactivity. AP and BNP belong to a family of neuropeptides that may be important in central cardiovascular control.

Original languageEnglish (US)
Pages (from-to)29-34
Number of pages6
JournalNeuroscience Letters
Volume96
Issue number1
DOIs
StatePublished - Jan 2 1989
Externally publishedYes

Fingerprint

Brain Natriuretic Peptide
Atrial Natriuretic Factor
Neuropeptides
Immune Sera
Swine
Central Nervous System
Peptides

Keywords

  • Atrial natriuretic peptide
  • Brain natriuretic peptide
  • Circumventricular organ
  • Nucleus of the solitary tract
  • Vasopressin neuron

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Saper, C. B., Hurley, K. M., Moga, M., Holmes, H. R., Adams, S. A., Leahy, K. M., & Needleman, P. (1989). Brain natriuretic peptides: Differential localization of a new family of neuropeptides. Neuroscience Letters, 96(1), 29-34. https://doi.org/10.1016/0304-3940(89)90238-3

Brain natriuretic peptides : Differential localization of a new family of neuropeptides. / Saper, Clifford B.; Hurley, Karen M.; Moga, Margaret; Holmes, H. Rodney; Adams, Steven A.; Leahy, Kathleen M.; Needleman, Philip.

In: Neuroscience Letters, Vol. 96, No. 1, 02.01.1989, p. 29-34.

Research output: Contribution to journalArticle

Saper, CB, Hurley, KM, Moga, M, Holmes, HR, Adams, SA, Leahy, KM & Needleman, P 1989, 'Brain natriuretic peptides: Differential localization of a new family of neuropeptides', Neuroscience Letters, vol. 96, no. 1, pp. 29-34. https://doi.org/10.1016/0304-3940(89)90238-3
Saper, Clifford B. ; Hurley, Karen M. ; Moga, Margaret ; Holmes, H. Rodney ; Adams, Steven A. ; Leahy, Kathleen M. ; Needleman, Philip. / Brain natriuretic peptides : Differential localization of a new family of neuropeptides. In: Neuroscience Letters. 1989 ; Vol. 96, No. 1. pp. 29-34.
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