Brain region effects of clozapine on amino acid and monoamine transmission

Bryan Yamamoto, E. A. Pehek, H. Y. Meltzer

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The purpose of the study was to compare the effects of clozapine and haloperidol on monoamine and amino acid transmission in limbic and extrapyramidal brain regions of the rat. In vivo microdialysis was used to measure the concentrations of neurotransmitters after acute and chronic drug administration. The acute administration of clozapine increased dopamine and glutamate in the medial prefrontal cortex and produced a greater increase, compared with haloperidol, in GABA (gamma-aminobutyric acid) efflux within the ventral pallidum. Chronic treatment with clozapine increased dopamine and serotonin in the medial prefrontal cortex. Chronic haloperidol administration increased glutamate in the striatum by fivefold whereas chronic clozapine treatment had no effect on striatal glutamate. Furthermore, chronic haloperidol administration transiently increased, then decreased. GABA efflux in the substantia nigra. Overall, clozapine has a preferential effect on mesocorticolimbic neurotransmission whereas haloperidol alters glutamate and GABA efflux within the extrapyramidal motor system.

Original languageEnglish (US)
Pages (from-to)8-14
Number of pages7
JournalJournal of Clinical Psychiatry
Volume55
Issue number9 SUPPL. B
StatePublished - 1994
Externally publishedYes

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Clozapine
Haloperidol
Glutamic Acid
Amino Acids
gamma-Aminobutyric Acid
Brain
Prefrontal Cortex
Dopamine
Corpus Striatum
Microdialysis
Substantia Nigra
Synaptic Transmission
Neurotransmitter Agents
Serotonin
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Brain region effects of clozapine on amino acid and monoamine transmission. / Yamamoto, Bryan; Pehek, E. A.; Meltzer, H. Y.

In: Journal of Clinical Psychiatry, Vol. 55, No. 9 SUPPL. B, 1994, p. 8-14.

Research output: Contribution to journalArticle

Yamamoto, Bryan ; Pehek, E. A. ; Meltzer, H. Y. / Brain region effects of clozapine on amino acid and monoamine transmission. In: Journal of Clinical Psychiatry. 1994 ; Vol. 55, No. 9 SUPPL. B. pp. 8-14.
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