Brainstem melanomas presenting as a cavernous malformation

A. Y. Lu, A. R. Patel, G. A. Kuzmik, K. K. Atsina, R. A. Bronen, P. M. Jabbour, D. M. Hasan, Alexander Vortmeyer, B. G. Welch, K. R. Bulsara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Melanoma lesions in the brainstem can be difficult to distinguish radiographically and clinically from cavernous malformations. However, the treatment modalities and clinical course of these two diseases differ considerably. We report two cases of melanoma presenting as brainstem hemorrhages. Case description: A 69-year-old male was found to have a hemorrhagic lesion of the right dorsal midbrain. After a repeat hemorrhage, the lesion was resected and found to be hyperchromatic. Nonetheless, the patient suffered rebleeding and died 3. months later. A 62-year-old female was similarly found to have an acute pontine hemorrhage. After resection of the lesion, she underwent whole-brain radiation therapy but ultimately died 5.5. months later. The histopathology of both lesions was consistent with melanoma. Conclusions: Melanoma in the brainstem can mimic cavernous malformations. While management of these lesions includes stereotactic radiosurgery, whole-brain radiation, and surgical resection, metastatic brainstem melanoma follows an aggressive clinical course with a poor prognosis.

Original languageEnglish (US)
Pages (from-to)184-187
Number of pages4
JournalNeurochirurgie
Volume60
Issue number4
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Brain Stem
Melanoma
Hemorrhage
Radiosurgery
Brain
Mesencephalon
Radiotherapy
Radiation
Therapeutics

Keywords

  • Brain stem
  • Cavernous malformations of CNS and retina
  • Melanoma

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Lu, A. Y., Patel, A. R., Kuzmik, G. A., Atsina, K. K., Bronen, R. A., Jabbour, P. M., ... Bulsara, K. R. (2014). Brainstem melanomas presenting as a cavernous malformation. Neurochirurgie, 60(4), 184-187. https://doi.org/10.1016/j.neuchi.2014.02.005

Brainstem melanomas presenting as a cavernous malformation. / Lu, A. Y.; Patel, A. R.; Kuzmik, G. A.; Atsina, K. K.; Bronen, R. A.; Jabbour, P. M.; Hasan, D. M.; Vortmeyer, Alexander; Welch, B. G.; Bulsara, K. R.

In: Neurochirurgie, Vol. 60, No. 4, 01.01.2014, p. 184-187.

Research output: Contribution to journalArticle

Lu, AY, Patel, AR, Kuzmik, GA, Atsina, KK, Bronen, RA, Jabbour, PM, Hasan, DM, Vortmeyer, A, Welch, BG & Bulsara, KR 2014, 'Brainstem melanomas presenting as a cavernous malformation', Neurochirurgie, vol. 60, no. 4, pp. 184-187. https://doi.org/10.1016/j.neuchi.2014.02.005
Lu AY, Patel AR, Kuzmik GA, Atsina KK, Bronen RA, Jabbour PM et al. Brainstem melanomas presenting as a cavernous malformation. Neurochirurgie. 2014 Jan 1;60(4):184-187. https://doi.org/10.1016/j.neuchi.2014.02.005
Lu, A. Y. ; Patel, A. R. ; Kuzmik, G. A. ; Atsina, K. K. ; Bronen, R. A. ; Jabbour, P. M. ; Hasan, D. M. ; Vortmeyer, Alexander ; Welch, B. G. ; Bulsara, K. R. / Brainstem melanomas presenting as a cavernous malformation. In: Neurochirurgie. 2014 ; Vol. 60, No. 4. pp. 184-187.
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