Brainstem metastases treated with Gamma Knife stereotactic radiosurgery

the Indiana University Health experience

Ajay Patel, Homan Mohammadi, Tuo Dong, Kevin Ren Yeh Shiue, Douglas Frye, Yi Le, Shaheryar Ansari, Gordon A. Watson, James Miller, Tim Lautenschlaeger

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Brainstem metastases offer a unique challenge in cancer treatment, yet stereotactic radiosurgery (SRS) has proven to be an effective modality in treating these tumors. This report discusses the clinical outcomes of patients with brainstem metastases treated at Indiana University with Gamma Knife (GK) radiosurgery from 2008 to 2016. 19 brainstem metastases from 14 patients who had follow-up brain imaging were identified. Median tumor volume was 0.04 cc (range: 0.01-2.0 cc). Median prescribed dose was 17.5 Gy to the 50% isodose line (range: 14-22 Gy). Median survival after GK SRS treatment to brainstem lesion was 17.2 months (range: 2.8-45.6 months). The experience at Indiana University confirms the safety and efficacy of range of GK SRS prescription doses (14-22 Gy) to brainstem metastases.

Original languageEnglish (US)
Pages (from-to)15-23
Number of pages9
JournalCNS oncology
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2018

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Radiosurgery
Brain Stem
Neoplasm Metastasis
Health
Tumor Burden
Neuroimaging
Prescriptions
Neoplasms
Safety
Survival
Therapeutics

Keywords

  • brainstem
  • Gamma Knife
  • metastasis
  • radiosurgery

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Patel, A., Mohammadi, H., Dong, T., Shiue, K. R. Y., Frye, D., Le, Y., ... Lautenschlaeger, T. (2018). Brainstem metastases treated with Gamma Knife stereotactic radiosurgery: the Indiana University Health experience. CNS oncology, 7(1), 15-23. https://doi.org/10.2217/cns-2017-0029

Brainstem metastases treated with Gamma Knife stereotactic radiosurgery : the Indiana University Health experience. / Patel, Ajay; Mohammadi, Homan; Dong, Tuo; Shiue, Kevin Ren Yeh; Frye, Douglas; Le, Yi; Ansari, Shaheryar; Watson, Gordon A.; Miller, James; Lautenschlaeger, Tim.

In: CNS oncology, Vol. 7, No. 1, 01.01.2018, p. 15-23.

Research output: Contribution to journalArticle

Patel, A, Mohammadi, H, Dong, T, Shiue, KRY, Frye, D, Le, Y, Ansari, S, Watson, GA, Miller, J & Lautenschlaeger, T 2018, 'Brainstem metastases treated with Gamma Knife stereotactic radiosurgery: the Indiana University Health experience', CNS oncology, vol. 7, no. 1, pp. 15-23. https://doi.org/10.2217/cns-2017-0029
Patel, Ajay ; Mohammadi, Homan ; Dong, Tuo ; Shiue, Kevin Ren Yeh ; Frye, Douglas ; Le, Yi ; Ansari, Shaheryar ; Watson, Gordon A. ; Miller, James ; Lautenschlaeger, Tim. / Brainstem metastases treated with Gamma Knife stereotactic radiosurgery : the Indiana University Health experience. In: CNS oncology. 2018 ; Vol. 7, No. 1. pp. 15-23.
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