Breaking Down Barriers to Chemoresistance: Role of Chemotherapy-Induced Osteoblastic Jagged1

Research output: Contribution to journalShort survey

Abstract

Bone metastases are incurable. The bone microenvironment has always been a suspect for this clinical enigma, but the exact mechanisms have been unclear. In this issue of Cancer Cell, Zheng and colleagues provide evidence that chemotherapy itself induces chemoresistance of bone metastases, mediated by osteoblast Jagged1-induced tumor Notch signaling. Bone metastases are incurable. The bone microenvironment has always been a suspect for this clinical enigma, but the exact mechanisms have been unclear. In this issue of Cancer Cell, Zheng and colleagues provide evidence that chemotherapy itself induces chemoresistance of bone metastases, mediated by osteoblast Jagged1-induced tumor Notch signaling.

Original languageEnglish (US)
Pages (from-to)717-718
Number of pages2
JournalCancer Cell
Volume32
Issue number6
DOIs
StatePublished - Dec 11 2017

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ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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