Breast lesions of uncertain malignant nature and limited metastatic potential: Proposals to improve their recognition and clinical management

Emad A. Rakha, Sunil Badve, Vincenzo Eusebi, Jorge S. Reis-Filho, Stephen B. Fox, David J. Dabbs, Thomas Decker, Zsolt Hodi, Shu Ichihara, Andrew H S Lee, José Palacios, Andrea L. Richardson, Anne Vincent-Salomon, Fernando C. Schmitt, Puay Hoon Tan, Gary M. Tse, Ian O. Ellis

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Breast lesions comprise a family of heterogeneous entities with variable patterns of presentation, morphology and clinical behaviour. The majority of breast lesions are classified traditionally into benign and malignant conditions and their behaviour can, in the vast majority of cases, be predicted with a reasonable degree of accuracy. However, there remain lesions which show borderline features and lie in a grey zone between benign and malignant, as their behaviour cannot be predicted reliably. Defined pathological categorization of such lesions is challenging, and for some entities is recognized to be subjective and include a range of diagnoses, and forms of terminology, which may trigger over- or undertreatment. The rarity of these lesions makes the acquisition of clinical evidence problematic and limits the development of a sufficient evidence base to support informed decision-making by clinicians and patients. Emerging molecular evidence is providing a greater understanding of the biology of these lesions, but this may or may not be reflected in their clinical behaviour. Herein we discuss some breast lesions that are associated with uncertainty regarding classification and behaviour, and hence management. These include biologically invasive malignant lesions associated with uncertain metastatic potential, such as low-grade adenosquamous carcinoma, low-grade fibromatosis-like spindle cell carcinoma and encapsulated papillary carcinoma. Other lesions of uncertain malignant nature remain, such as mammary cylindroma, atypical microglandular adenosis, mammary pleomorphic adenoma and infiltrating epitheliosis. The concept of categories of (1) breast lesions of uncertain malignant nature and (2) breast lesions of limited metastatic potential are proposed with details of which histological entities could be included in each category, and their management implications are discussed.

Original languageEnglish (US)
Pages (from-to)45-56
Number of pages12
JournalHistopathology
Volume68
Issue number1
DOIs
StatePublished - Jan 1 2016

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Breast
Fibrocystic Breast Disease
Adenosquamous Carcinoma
Pleomorphic Adenoma
Adenoid Cystic Carcinoma
Fibroma
Papillary Carcinoma
Terminology
Uncertainty
Recognition (Psychology)
Decision Making
Carcinoma

Keywords

  • Behaviour
  • Breast lesions
  • Differentiation
  • Lesions of uncertain malignant potential
  • Lesions of uncertain metastatic potential
  • Terminology

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

Breast lesions of uncertain malignant nature and limited metastatic potential : Proposals to improve their recognition and clinical management. / Rakha, Emad A.; Badve, Sunil; Eusebi, Vincenzo; Reis-Filho, Jorge S.; Fox, Stephen B.; Dabbs, David J.; Decker, Thomas; Hodi, Zsolt; Ichihara, Shu; Lee, Andrew H S; Palacios, José; Richardson, Andrea L.; Vincent-Salomon, Anne; Schmitt, Fernando C.; Tan, Puay Hoon; Tse, Gary M.; Ellis, Ian O.

In: Histopathology, Vol. 68, No. 1, 01.01.2016, p. 45-56.

Research output: Contribution to journalArticle

Rakha, EA, Badve, S, Eusebi, V, Reis-Filho, JS, Fox, SB, Dabbs, DJ, Decker, T, Hodi, Z, Ichihara, S, Lee, AHS, Palacios, J, Richardson, AL, Vincent-Salomon, A, Schmitt, FC, Tan, PH, Tse, GM & Ellis, IO 2016, 'Breast lesions of uncertain malignant nature and limited metastatic potential: Proposals to improve their recognition and clinical management', Histopathology, vol. 68, no. 1, pp. 45-56. https://doi.org/10.1111/his.12861
Rakha, Emad A. ; Badve, Sunil ; Eusebi, Vincenzo ; Reis-Filho, Jorge S. ; Fox, Stephen B. ; Dabbs, David J. ; Decker, Thomas ; Hodi, Zsolt ; Ichihara, Shu ; Lee, Andrew H S ; Palacios, José ; Richardson, Andrea L. ; Vincent-Salomon, Anne ; Schmitt, Fernando C. ; Tan, Puay Hoon ; Tse, Gary M. ; Ellis, Ian O. / Breast lesions of uncertain malignant nature and limited metastatic potential : Proposals to improve their recognition and clinical management. In: Histopathology. 2016 ; Vol. 68, No. 1. pp. 45-56.
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