Bridged α-helix mimetic small molecules

Yeongju Lee, Haeri Im, Sanket Das, Misook Oh, Ji Hoon Lee, Sihyun Ham, Hyun Suk Lim

Research output: Contribution to journalArticle

Abstract

Herein, we report a strategy for generating conformationally restricted α-helix mimetic small molecules by introducing covalent bridges that limit rotation about the central axis of α-helix mimetics. We demonstrate that the bridged α-helix mimetics have enhanced binding affinity and specificity to the target protein due to the restricted conformation as well as extra interaction of the bridge with the protein surface.

Original languageEnglish (US)
Pages (from-to)13311-13314
Number of pages4
JournalChemical Communications
Volume55
Issue number88
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

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Proteins
Molecules
Conformations
Membrane Proteins

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Lee, Y., Im, H., Das, S., Oh, M., Lee, J. H., Ham, S., & Lim, H. S. (2019). Bridged α-helix mimetic small molecules. Chemical Communications, 55(88), 13311-13314. https://doi.org/10.1039/c9cc03627j

Bridged α-helix mimetic small molecules. / Lee, Yeongju; Im, Haeri; Das, Sanket; Oh, Misook; Lee, Ji Hoon; Ham, Sihyun; Lim, Hyun Suk.

In: Chemical Communications, Vol. 55, No. 88, 01.01.2019, p. 13311-13314.

Research output: Contribution to journalArticle

Lee, Y, Im, H, Das, S, Oh, M, Lee, JH, Ham, S & Lim, HS 2019, 'Bridged α-helix mimetic small molecules', Chemical Communications, vol. 55, no. 88, pp. 13311-13314. https://doi.org/10.1039/c9cc03627j
Lee Y, Im H, Das S, Oh M, Lee JH, Ham S et al. Bridged α-helix mimetic small molecules. Chemical Communications. 2019 Jan 1;55(88):13311-13314. https://doi.org/10.1039/c9cc03627j
Lee, Yeongju ; Im, Haeri ; Das, Sanket ; Oh, Misook ; Lee, Ji Hoon ; Ham, Sihyun ; Lim, Hyun Suk. / Bridged α-helix mimetic small molecules. In: Chemical Communications. 2019 ; Vol. 55, No. 88. pp. 13311-13314.
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