Bridged α-helix mimetic small molecules

Yeongju Lee, Haeri Im, Sanket Das, Misook Oh, Ji Hoon Lee, Sihyun Ham, Hyun Suk Lim

Research output: Contribution to journalArticle


Herein, we report a strategy for generating conformationally restricted α-helix mimetic small molecules by introducing covalent bridges that limit rotation about the central axis of α-helix mimetics. We demonstrate that the bridged α-helix mimetics have enhanced binding affinity and specificity to the target protein due to the restricted conformation as well as extra interaction of the bridge with the protein surface.

Original languageEnglish (US)
Pages (from-to)13311-13314
Number of pages4
JournalChemical Communications
Issue number88
StatePublished - Jan 1 2019
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Bridged α-helix mimetic small molecules'. Together they form a unique fingerprint.

  • Cite this

    Lee, Y., Im, H., Das, S., Oh, M., Lee, J. H., Ham, S., & Lim, H. S. (2019). Bridged α-helix mimetic small molecules. Chemical Communications, 55(88), 13311-13314.