Brief report: Endothelial colony-forming cells and inflammatory monocytes in HIV

Travis R. Hays, Julie A. Mund, Ziyue Liu, Jamie Case, David A. Ingram, Samir K. Gupta

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The relationships between HIV infection, monocyte activation, and endothelial colony-forming cells (ECFCs) are unknown. We compared ECFC, intermediate monocytes (CD14 + CD16 +), and nonclassical monocytes (CD14 dim CD16 ++) levels in HIV-infected participants virologically suppressed on antiretroviral therapy, HIV-infected treatment-naive participants, and HIV-uninfected healthy controls. ECFC levels were significantly higher in the HIV-infected virologically suppressed group compared with the uninfected controls. CD14 + CD16 + percentages (but not CD14 dim CD16 ++ cells) were significantly higher in both HIV-infected groups vs. uninfected controls. In the HIV-infected groups, ECFCs and CD14 + CD16 + intermediate monocytes were significantly and inversely correlated. Lower availability of ECFCs may partly explain the relationship between greater intermediate monocytes and atherosclerosis in HIV.

Original languageEnglish (US)
Pages (from-to)550-553
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Volume68
Issue number5
DOIs
StatePublished - Apr 15 2015

Keywords

  • endothelial colony-forming cells
  • endothelial progenitor cell
  • flow-mediated dilation
  • HIV
  • intermediate monocyte
  • nonclassical monocyte

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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