Bronchodilator responsiveness in infants with bronchiolitis.

Robert Tepper, D. Rosenberg, H. Eigen, T. Reister

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

We evaluated 34 infants with bronchiolitis, (17 of both genders; mean age, 4.6 mos; ranges, 0.7-14.5 mos). The 20 inpatients were significantly younger than the 14 outpatients (2.6 vs. 8.2 months, P < 0.05), and more females were inpatients. Forced expiratory flows at functional residual capacity (VmaxFRC) were obtained at baseline, after aerosolized normal saline (NS), and metaproterenol (0.025 mL/kg in 2 mL NS). Flows were expressed as Z-scores, the difference between the measured and predicted flows, divided by the standard deviation for the predicted value. At baseline, outpatients were more obstructed than inpatients (-1.64 vs. -0.95, P < 0.05), infants > 2 months old were more obstructed than infants < or = 2 months old (-1.54 vs. -0.80, P < 0.05), and males more than females (-1.45 vs. -1.02, P < 0.05). Following NS the whole group had a small but significant decrease in Z-scores (-1.23 to -1.31, P < 0.05). Following metaproterenol, the younger infants had significantly (P < 0.05) higher Z-scores compared to baseline and NS (-0.80 vs. -0.86 vs. -0.59). However, no significant changes occurred in older infants. Females also had an increased flow after metaproterenol and were less obstructed than after NS (-1.11 vs. -0.86, P < 0.015). In males no increased flows occurred after metaproterenol (-1.45 vs. -1.48). Bronchodilator responsiveness did not relate to severity of airway obstruction, history of family asthma, allergy, or passive smoke exposure. We conclude that inhaled metaproterenol improves airway function in a subgroup of infants with bronchiolitis, but the subgroup could not clearly be identified because age and gender were confounding factors.

Original languageEnglish
Pages (from-to)81-85
Number of pages5
JournalPediatric Pulmonology
Volume17
Issue number2
StatePublished - Feb 1994

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Bronchiolitis
Metaproterenol
Bronchodilator Agents
Airway Obstruction
Smoke
Inpatients
Hypersensitivity
Outpatients
Asthma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Tepper, R., Rosenberg, D., Eigen, H., & Reister, T. (1994). Bronchodilator responsiveness in infants with bronchiolitis. Pediatric Pulmonology, 17(2), 81-85.

Bronchodilator responsiveness in infants with bronchiolitis. / Tepper, Robert; Rosenberg, D.; Eigen, H.; Reister, T.

In: Pediatric Pulmonology, Vol. 17, No. 2, 02.1994, p. 81-85.

Research output: Contribution to journalArticle

Tepper, R, Rosenberg, D, Eigen, H & Reister, T 1994, 'Bronchodilator responsiveness in infants with bronchiolitis.', Pediatric Pulmonology, vol. 17, no. 2, pp. 81-85.
Tepper, Robert ; Rosenberg, D. ; Eigen, H. ; Reister, T. / Bronchodilator responsiveness in infants with bronchiolitis. In: Pediatric Pulmonology. 1994 ; Vol. 17, No. 2. pp. 81-85.
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