Budesonide use in pediatric crohn disease

Anthony Otley, Neal Leleiko, Christine Langton, Trudy Lerer, David MacK, Jonathan Evans, Marian Pfefferkorn, Ryan Carvalho, Joel Rosh, Anne Griffiths, Maria Oliva-Hemker, Marsha Kay, Athos Bousvaros, Michael Stephens, Charles Samson, Andrew Grossman, David Keljo, James Markowitz, Jeffrey Hyams

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4 Scopus citations

Abstract

BACKGROUND AND AIM:: Budesonide (BUD) is being used in pediatric Crohn disease (CD) because it is believed to have the potential to reduce corticosteroid-related toxicity; however, few data are available describing its use. The aim of the present study was to describe BUD use in an inception cohort of pediatric patients with CD. METHODS:: Data were derived from the prospective Pediatric IBD Collaborative Research Group Registry established in 2002 in North America. Use of BUD in children with CD was examined. RESULTS:: BUD was used in 119 of 932 (13%) of children with newly diagnosed CD, with 56 of 119 (47%) starting BUD ≤30 days of diagnosis (26/56 with ileum and/or ascending colon [IAC] disease). BUD was used as monotherapy (9%), in combination with 5-aminosalicylates (77%), or in combination with immunomodulators (43%). Forty-three percent (24/56) went on to receive conventional corticosteroid at some point following their first BUD course. For the 63 of 119 (53%) who started BUD beyond the diagnosis period, 51 of 63 (81%) also received prednisone, with BUD used as a means of weaning from prednisone in 17 of 63 (27%). Patients with IAC disease who received BUD ≤30 days of diagnosis were just as likely to have received conventional corticosteroids by 1 year as were those who did not receive BUD ≤30 days of diagnosis. Two-thirds (77/119) of patients received BUD for ≤6 months. CONCLUSIONS:: BUD is being used among pediatric patients newly diagnosed as having CD, although the majority does not have disease limited to the IAC. BUD monotherapy was rare, and further data are required to better define the role of BUD in the treatment of pediatric CD.

Original languageEnglish (US)
Pages (from-to)200-204
Number of pages5
JournalJournal of pediatric gastroenterology and nutrition
Volume55
Issue number2
DOIs
StatePublished - Aug 1 2012

Keywords

  • budesonide
  • corticosteroid
  • crohn disease
  • pediatric

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

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    Otley, A., Leleiko, N., Langton, C., Lerer, T., MacK, D., Evans, J., Pfefferkorn, M., Carvalho, R., Rosh, J., Griffiths, A., Oliva-Hemker, M., Kay, M., Bousvaros, A., Stephens, M., Samson, C., Grossman, A., Keljo, D., Markowitz, J., & Hyams, J. (2012). Budesonide use in pediatric crohn disease. Journal of pediatric gastroenterology and nutrition, 55(2), 200-204. https://doi.org/10.1097/MPG.0b013e31824a09c2