Building a surface atlas of hippocampal subfields from MRI scans using FreeSurfer, FIRST and SPHARM

Shan Cong, Maher Rizkalla, Eliza Y. Du, John West, Shannon Risacher, Andrew Saykin, Li Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Abstract

The hippocampus is widely studied with neuroimaging techniques given its importance in learning and memory and its potential as a biomarker for brain disorders such as Alzheimer's disease and epilepsy. However, its complex folding anatomy often presents analytical challenges. In particular, the critical hippocampal subfield information is usually ignored by hippocampal registration in detailed morphometric studies. Such an approach is thus inadequate to accurately characterize hippocampal morphometry and effectively identify hippocampal structural changes related to different conditions. To bridge this gap, we present our initial effort towards building a computational framework for subfield-guided hippocampal morphometry. This initial effort is focused on surface-based morphometry and aims to build a surface atlas of hippocampal subfields. Using the FreeSurfer software package, we obtain valuable hippocampal subfield information. Using the FIRST software package, we extract reliable hippocampal surface information. Using SPHARM, we develop an approach to create an atlas by mapping interpolated subfield information onto an average surface. The empirical result using ADNI data demonstrates the promise and good reproducibility of the proposed method.

Original languageEnglish (US)
Title of host publication2014 IEEE 57th International Midwest Symposium on Circuits and Systems, MWSCAS 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages813-816
Number of pages4
ISBN (Electronic)9781479941346, 9781479941346
DOIs
StatePublished - Sep 23 2014
Event2014 IEEE 57th International Midwest Symposium on Circuits and Systems, MWSCAS 2014 - College Station, United States
Duration: Aug 3 2014Aug 6 2014

Publication series

NameMidwest Symposium on Circuits and Systems
ISSN (Print)1548-3746

Other

Other2014 IEEE 57th International Midwest Symposium on Circuits and Systems, MWSCAS 2014
CountryUnited States
CityCollege Station
Period8/3/148/6/14

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

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