C-cell hyperplasia developing in residual thyroid following resection for sporadic medullary carcinoma

Thomas Ulbright, F. T. Kraus, L. W. O'Neal.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Four years following resection of a medullary carcinoma of the thyroid, a 49-year-old man experienced elevated serum calcitonin levels. There was no evidence of metastasis. A re-exploration of the patient's neck demonstrated a histologically normal thyroid remnant that demonstrated C-cell hyperplasia by immunoperoxidase staining. The lack of a familial history, a normal parathyroid, and the absence of C-cell hyperplasia in non-tumerous thyroid of the original resection support the concept that the patient had a sporadic tumor. Patients who have undergone incomplete thyroidecytomies for non0familial disease are at risk for developing C-cell proliferations and possibly medullary carcinoma. We conclude that the C-cell hyperplasia in this thyroid remnant is the source of the elevated calcitonin level; this mechanism may be also explain postopratively elevated calcitonin levels in some patients with medullary carcinoma treated by partial thyroidectomy and high calcitonin levels for a variable period after complete thyroidectomy.

Original languageEnglish (US)
Pages (from-to)2076-2079
Number of pages4
JournalCancer
Volume48
Issue number9
StatePublished - 1981
Externally publishedYes

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Medullary Carcinoma
Calcitonin
Hyperplasia
Thyroid Gland
Thyroidectomy
Neck
History
Cell Proliferation
Staining and Labeling
Neoplasm Metastasis
Serum
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

C-cell hyperplasia developing in residual thyroid following resection for sporadic medullary carcinoma. / Ulbright, Thomas; Kraus, F. T.; O'Neal., L. W.

In: Cancer, Vol. 48, No. 9, 1981, p. 2076-2079.

Research output: Contribution to journalArticle

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